Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | TNK2 | Q07912 | 4/20 | 0.36 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.33 |
| ▸ | POLRMT | O00411 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20144183 | 1.00 | HRH4 (0.47) | HRH4HRH3TAAR1TNK2HSPA5 | |
| SCHEMBL25948690 | 0.85 | HRH4 (0.45) | HRH4HRH3TAAR1HSPA5LMNA | |
| SCHEMBL23584542 | 0.85 | HRH4 (0.45) | HRH4HRH3TAAR1HSPA5LMNA | |
| SCHEMBL24160862 | 0.85 | HRH4 (0.49) | HRH4HRH3TAAR1TNK2HSPA5 | |
| SCHEMBL18666890 | 0.82 | HSPA5 (0.36) | HRH4HRH3TAAR1TNK2HSPA5 | |
| SCHEMBL24606380 | 0.81 | NPC1 (0.38) | LMNADOT1L | |
| SCHEMBL24736805 | 0.81 | PDE4D (0.38) | TAAR1HSPA5DOT1L | |
| SCHEMBL20144205 | 0.80 | DOT1L (0.35) | TNK2DOT1LPOLRMT | |
| SCHEMBL19343932 | 0.79 | HRH4 (0.54) | HRH4HRH3TAAR1LMNADRD1 | |
| SCHEMBL19344220 | 0.79 | CYP2A6 (0.39) | TNK2LMNADOT1LPOLRMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426664-B1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-06-30 | — | — | EP | disclosed |