Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.32 |
| ▸ | CTSB | P07858 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20144183 | 0.79 | HRH4 (0.47) | HRH4HRH3LMNADRD1TAAR1 | |
| SCHEMBL23584717 | 0.79 | HRH4 (0.47) | HRH4HRH3LMNADRD1TAAR1 | |
| SCHEMBL20144193 | 0.79 | CYP2A6 (0.45) | HRH4HRH3CYP2A6 | |
| SCHEMBL18667091 | 0.79 | CYP2A6 (0.45) | HRH4HRH3CYP2A6 | |
| SCHEMBL23584542 | 0.77 | HRH4 (0.45) | HRH4HRH3LMNADRD1TAAR1 | |
| SCHEMBL25948690 | 0.77 | HRH4 (0.45) | HRH4HRH3LMNADRD1TAAR1 | |
| SCHEMBL24160862 | 0.76 | HRH4 (0.49) | HRH4HRH3LMNADRD1TAAR1 | |
| SCHEMBL23369202 | 0.70 | HRH4 (0.52) | HRH4HRH3LMNADRD1TAAR1 | |
| SCHEMBL20231377 | 0.68 | HRH4 (0.56) | HRH4HRH3LMNADRD1TAAR1 | |
| SCHEMBL20234410 | 0.68 | HRH4 (0.56) | HRH4HRH3LMNADRD1TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017153186-A1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-09-14 | — | — | WO | disclosed |