Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAO1 | P09471 | 5/20 | 0.39 |
| ▸ | GNAI3 | P08754 | 4/20 | 0.39 |
| ▸ | GNAI1 | P63096 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | LSS | P48449 | 2/20 | 0.34 |
| ▸ | GGPS1 | O95749 | 3/20 | 0.33 |
| ▸ | BCHE | P06276 | 2/20 | 0.32 |
| ▸ | NCF1 | P14598 | 1/20 | 0.31 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.30 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24764709 | 0.86 | GNAO1 (0.48) | GNAO1GNAI3GNAI1BCHE | |
| SCHEMBL26404311 | 0.77 | GNAO1 (0.38) | GNAO1GNAI3GNAI1LMNAGGPS1 | |
| SCHEMBL23696294 | 0.77 | GNAO1 (0.33) | GNAO1GNAI3GNAI1LMNAGGPS1 | |
| SCHEMBL19286115 | 0.77 | GNAO1 (0.49) | GNAO1GNAI3GNAI1LSSNCF1 | |
| SCHEMBL14539276 | 0.77 | GNAO1 (0.49) | GNAO1GNAI3GNAI1LSSNCF1 | |
| SCHEMBL21725620 | 0.77 | GNAO1 (0.49) | GNAO1GNAI3GNAI1LSSNCF1 | |
| SCHEMBL18885285 | 0.77 | GNAO1 (0.49) | GNAO1GNAI3GNAI1LSSNCF1 | |
| SCHEMBL28740098 | 0.77 | GNAO1 (0.49) | GNAO1GNAI3GNAI1LSSNCF1 | |
| Hydrochloric Acid SCHEMBL23004465 | 0.76 | GNAO1 (0.51) | GNAO1GNAI3GNAI1LSSNCF1 | |
| Iodide SCHEMBL15008877 | 0.76 | GNAO1 (0.47) | GNAO1GNAI3GNAI1LSSNCF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11548870-B2 | Compounds useful as inhibitors of helios protein | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-01-10 | — | — | US | disclosed |
| US-20210147383-A1 | COMPOUNDS USEFUL AS INHIBITORS OF HELIOS PROTEIN | BRISTOL-MYERS SQUIBB COMPANY | 2021-05-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210147383-A1 | COMPOUNDS USEFUL AS INHIBITORS OF HELIOS PROTEIN | IKZF2, RPL6, HNRNPR | GNAO1 2230/4885GNAI3 1832/4885GNAI1 1773/4885 |
| US-11548870-B2 | Compounds useful as inhibitors of helios protein | IKZF2, RPL6, HNRNPR | GNAO1 2230/4885GNAI3 1832/4885GNAI1 1773/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.