Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | THRA | P10827 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22675502 | 1.00 | SMN1; SMN2 (0.52) | SMN1; SMN2GAATP53LTA4HALDH1A1 | |
| SCHEMBL16556615 | 1.00 | SMN1; SMN2 (0.52) | SMN1; SMN2GAATP53LTA4HALDH1A1 | |
| SCHEMBL13676412 | 0.89 | KDM4E (0.50) | SMN1; SMN2GAAALDH1A1KDM2BKDM4E | |
| SCHEMBL10516690 | 0.89 | SMN1; SMN2 (0.60) | SMN1; SMN2GAATP53ALDH1A1POLB | |
| SCHEMBL13146450 | 0.86 | LTA4H (0.51) | SMN1; SMN2GAATP53LTA4HALDH1A1 | |
| SCHEMBL10195966 | 0.84 | BRD4 (0.44) | SMN1; SMN2GAATP53LTA4HALDH1A1 | |
| SCHEMBL26207326 | 0.84 | MAPT (0.54) | SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL8518749 | 0.83 | BCHE (0.50) | SMN1; SMN2GAATP53LTA4HTHRA | |
| SCHEMBL24519291 | 0.82 | SMN1; SMN2 (0.54) | SMN1; SMN2GAATP53ALDH1A1POLB | |
| SCHEMBL2471369 | 0.82 | LTA4H (0.48) | SMN1; SMN2GAATP53LTA4HALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023006019-A1 | POLYSUBSTITUTED BENZENE PD-L1 INHIBITOR, COMPOSITION AND USE THEREOF | 杭州和正医药有限公司 | 2023-02-02 | — | — | WO | disclosed |
| WO-2021093817-A1 | IMMUNOMODULATORY COMPOUNDS, COMPOSITION AND APPLICATION THEREOF | 杭州和正医药有限公司 | 2021-05-20 | — | — | WO | disclosed |