Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.60 |
| ▸ | METAP2 | P50579 | 1/20 | 0.46 |
| ▸ | SCN10A | Q9Y5Y9 | 8/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | CHUK | O15111 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | PAK4 | O96013 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | PRKCG | P05129 | 1/20 | 0.41 |
| ▸ | INSR | P06213 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19424168 | 0.78 | PDE10A (0.45) | PDE10AMETAP2TRPV1 | |
| SCHEMBL15038254 | 0.75 | PDE10A (1.00) | PDE10AMETAP2SCN10AKCNH2 | |
| SCHEMBL21022998 | 0.75 | PDE10A (0.46) | PDE10AMETAP2SCN10AKCNH2PLK4 | |
| SCHEMBL418110 | 0.73 | CYP1A2 (0.57) | ABL1TRPV1 | |
| SCHEMBL12190473 | 0.72 | SCN10A (0.58) | PDE10AMETAP2SCN10AKCNH2PLK4 | |
| SCHEMBL23479213 | 0.71 | PDE10A (0.46) | PDE10AMETAP2SCN10AKCNH2PLK4 | |
| SCHEMBL15945343 | 0.71 | SCN10A (0.62) | PDE10AMETAP2SCN10AKCNH2SCD | |
| SCHEMBL2633082 | 0.71 | CYP1A2 (0.50) | TRPV1 | |
| SCHEMBL19341334 | 0.69 | KCNH2 (0.40) | PDE10AKCNH2TRPV1 | |
| SCHEMBL23479517 | 0.69 | PDE10A (0.43) | PDE10AMETAP2SCN10AKCNH2PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11541046-B2 | Spirolactone compounds | QUIXGEN, INC. (US) | 2023-01-03 | — | — | US | disclosed |
| US-20210145822-A1 | Novel Spirolactone Compounds | QUIXGEN, INC. (US) | 2021-05-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11541046-B2 | Spirolactone compounds | ACACA, AKR1C2, AKR1A1 | PDE10A 2486/4885METAP2 3249/4885SCN10A 822/4885 |
| US-20210145822-A1 | Novel Spirolactone Compounds | ACACA, HSD17B10, AKR1C2 | PDE10A 2247/4885METAP2 3448/4885SCN10A 672/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.