Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NMT1 | P30419 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | FPR2 | P25090 | 1/20 | 0.34 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12156840 | 0.81 | PIK3CD (0.44) | MEN1KMT2AALDH1A1SIGMAR1 | |
| SCHEMBL13920851 | 0.81 | MEN1 (0.37) | MEN1KMT2AALDH1A1GAANMT1 | |
| SCHEMBL12156842 | 0.81 | MEN1 (0.37) | MEN1KMT2AALDH1A1GAANMT1 | |
| SCHEMBL2331440 | 0.81 | SIGMAR1 (0.39) | NMT1SIGMAR1 | |
| Hydrochloric Acid SCHEMBL2338785 | 0.81 | MEN1 (0.37) | MEN1KMT2AALDH1A1GAANMT1 | |
| Hydrochloric Acid SCHEMBL2332832 | 0.81 | PIK3CD (0.44) | MEN1KMT2AALDH1A1 | |
| SCHEMBL12156838 | 0.80 | MEN1 (0.36) | MEN1KMT2AALDH1A1GAANMT1 | |
| Hydrochloric Acid SCHEMBL2339252 | 0.79 | MEN1 (0.36) | MEN1KMT2AALDH1A1GAANMT1 | |
| SCHEMBL12156839 | 0.79 | MEN1 (0.36) | MEN1KMT2AALDH1A1GAANMT1 | |
| SCHEMBL2332852 | 0.79 | SIGMAR1 (0.46) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8048884-B2 | Substituted piperazinyl pyrazines and pyridines as 5-HT7 receptor antagonists | ELI LILLY AND COMPANY (US) | 2011-11-01 | — | — | US | disclosed |
| EP-2188268-B1 | SUBSTITUTED PIPERAZINYL PYRAZINES AND PYRIDINES AS 5-HT7 RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2011-08-17 | — | — | EP | disclosed |