Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.39 |
| ▸ | HTR1A | P08908 | 6/20 | 0.37 |
| ▸ | DRD2 | P14416 | 6/20 | 0.37 |
| ▸ | HTR2A | P28223 | 6/20 | 0.37 |
| ▸ | HTR7 | P34969 | 6/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NMT1 | P30419 | 1/20 | 0.33 |
| ▸ | CFTR | P13569 | 1/20 | 0.32 |
| ▸ | CCR5 | P51681 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2332852 | 0.85 | SIGMAR1 (0.46) | SIGMAR1ADRB2MAPTHTTCFTR | |
| SCHEMBL2334111 | 0.85 | SIGMAR1 (0.39) | SIGMAR1HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL2335229 | 0.83 | SIGMAR1 (0.40) | SIGMAR1HTR1ADRD2HTR2AADRB2 | |
| SCHEMBL12156834 | 0.82 | HTR1A (0.36) | SIGMAR1HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL2337744 | 0.81 | MEN1 (0.42) | SIGMAR1NMT1 | |
| Hydrochloric Acid SCHEMBL2334287 | 0.81 | HTR1A (0.36) | SIGMAR1HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL12156829 | 0.81 | HRH3 (0.38) | SIGMAR1HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL12156828 | 0.81 | PIK3CD (0.48) | SIGMAR1HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL2336452 | 0.81 | HTR1A (0.39) | SIGMAR1HTR1ADRD2HTR2AHTR7 | |
| Hydrochloric Acid SCHEMBL2332468 | 0.80 | PIK3CD (0.47) | SIGMAR1HTR1ADRD2HTR2AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8048884-B2 | Substituted piperazinyl pyrazines and pyridines as 5-HT7 receptor antagonists | ELI LILLY AND COMPANY (US) | 2011-11-01 | — | — | US | disclosed |
| EP-2188268-B1 | SUBSTITUTED PIPERAZINYL PYRAZINES AND PYRIDINES AS 5-HT7 RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2011-08-17 | — | — | EP | disclosed |