Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.45 |
| ▸ | DRD2 | P14416 | 4/20 | 0.44 |
| ▸ | DRD3 | P35462 | 5/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 4/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | DRD1 | P21728 | 2/20 | 0.41 |
| ▸ | DRD5 | P21918 | 2/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | PRCP | P42785 | 1/20 | 0.41 |
| ▸ | EBP | Q15125 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29932789 | 0.92 | OPRL1 (0.46) | OPRL1OPRM1OPRD1DRD2DRD3 | |
| SCHEMBL23364743 | 0.92 | OPRL1 (0.46) | OPRL1OPRM1OPRD1DRD2DRD3 | |
| SCHEMBL23364686 | 0.78 | OPRM1 (0.44) | OPRL1OPRM1OPRD1DRD2DRD3 | |
| SCHEMBL29933156 | 0.78 | OPRM1 (0.44) | OPRL1OPRM1OPRD1DRD2DRD3 | |
| SCHEMBL23380182 | 0.74 | OPRL1 (0.45) | OPRL1OPRM1OPRD1DRD2DRD3 | |
| SCHEMBL1608042 | 0.73 | DRD2 (0.59) | OPRL1DRD2DRD3DRD4SIGMAR1 | |
| SCHEMBL29427014 | 0.73 | DRD2 (0.59) | OPRL1DRD2DRD3DRD4SIGMAR1 | |
| SCHEMBL13289736 | 0.71 | DRD2 (0.56) | OPRL1DRD2DRD3DRD4SIGMAR1 | |
| SCHEMBL23380190 | 0.71 | HTR2C (0.37) | OPRL1OPRM1OPRD1DRD2DRD3 | |
| SCHEMBL23364785 | 0.70 | KDM1A (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021097057-A1 | 5-MEMBERED HETEROARYLAMINOSULFONAMIDES FOR TREATING CONDITIONS MEDIATED BY DEFICIENT CFTR ACTIVITY | GENZYME CORPORATION (US) | 2021-05-20 | — | — | WO | disclosed |