SCHEMBL233828

SCHEMBL233828

COc1cc([O])cc(OC)c1

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.69
CYP1A1 P04798 6/20 0.50
CYP1B1 Q16678 6/20 0.50
CYP3A4 P08684 3/20 0.44
CYP1A2 P05177 3/20 0.44
CYP2E1 P05181 2/20 0.44
CYP2C8 P10632 2/20 0.44
CYP2D6 P10635 2/20 0.44
CYP2A6 P11509 2/20 0.44
CYP2C9 P11712 2/20 0.44
CYP4B1 P13584 2/20 0.44
CYP2B6 P20813 2/20 0.44
CYP3A5 P20815 2/20 0.44
CYP2A7 P20853 2/20 0.44
CYP3A7 P24462 2/20 0.44
CYP2F1 P24903 2/20 0.44
CYP2C18 P33260 2/20 0.44
CYP2C19 P33261 2/20 0.44
CYP2J2 P51589 2/20 0.44
CYP4F2 P78329 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1805052 0.84 ALDH1A1 (0.48) ALDH1A1CYP1A1CYP1B1CYP3A4CA12
1,3,5-Trimethoxybenzene SCHEMBL28493 0.83 ALDH1A1 (1.00) ALDH1A1CYP1A1CYP1B1CYP3A4CYP1A2
SCHEMBL17203652 0.82 ALDH1A1 (0.46) ALDH1A1CYP1A1CYP1B1CYP3A4CYP1A2
SCHEMBL522122 0.82 ALDH1A1 (0.46) ALDH1A1CYP1A1CYP1B1CYP3A4CA12
SCHEMBL3842796 0.82 ALDH1A1 (0.46) ALDH1A1CYP1A1CYP1B1CYP3A4CYP1A2
SCHEMBL17204349 0.82 ALDH1A1 (0.46) ALDH1A1CYP1A1CYP1B1CYP3A4CYP1A2
1,3,5-Trimethoxybenzene SCHEMBL28834629 0.80 ALDH1A1 (0.79) ALDH1A1CYP1A1CYP1B1CYP3A4CYP1A2
1,3,5-Trimethoxybenzene SCHEMBL28740008 0.79 ALDH1A1 (0.92) ALDH1A1CYP1A1CYP1B1CYP3A4CYP1A2
1,3,5-Trimethoxybenzene SCHEMBL28416912 0.79 ALDH1A1 (0.92) ALDH1A1CYP1A1CYP1B1CYP3A4CYP1A2
1,3,5-Trimethoxybenzene SCHEMBL28557531 0.79 ALDH1A1 (0.92) ALDH1A1CYP1A1CYP1B1CYP3A4CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 803 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2970328-B1 NOVEL INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A ABBVIE DEUTSCHLAND (DE) 2017-04-26 EP claimed
EP-2970328-A1 NOVEL INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A AbbVie Deutschland GmbH & Co. KG (DE) 2016-01-20 EP claimed
US-9200005-B2 Inhibitor compounds of phosphodiesterase type 10A AbbVie Deutschland GmbH & Co. KG (DE) 2015-12-01 US claimed
WO-2014140086-A1 NOVEL INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A AbbVie Deutschland GmbH & Co. KG (DE) 2014-09-18 WO claimed
US-20140275069-A1 Novel inhibitor compounds of phosphodiesterase type 10A AbbVie Deutschland GmbH & Co. KG (DE) 2014-09-18 US claimed
US-20100130784-A1 SUBSTITUTED 1,1,1-TRIFLUORO-3-[(BENZYL)-(PYRIMIDIN-2-YL)-AMINO]-PROPAN-2-OL COMPOUNDS PFIZER INC. 2010-05-27 US claimed
EP-1115693-B9 SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL $i(TERTIARY)-HETEROALKYLAMINES USEFUL FOR INHIBITING CHOLESTERYL ESTER TRANSFER PROTEIN ACTIVITY MONSANTO CO (US) 2007-12-19 EP claimed
EP-1856060-A1 SUBSTITUTED 1,1,1-TRIFLUORO-3-[(BENZYL)-(PYRIMIDIN-2-YL)-AMINO]-PROP AN-2-OL COMPOUNDS Pfizer Products Inc. (US) 2007-11-21 EP claimed
EP-1115693-B1 SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL $i(TERTIARY)-HETEROALKYLAMINES USEFUL FOR INHIBITING CHOLESTERYL ESTER TRANSFER PROTEIN ACTIVITY MONSANTO CO (US) 2007-05-02 EP claimed
US-7122536-B2 (R)-chiral halogenated substituted fused heterocyclic amino compounds useful for inhibiting cholesterol ester transfer protein activity PFIZER INC. (US) 2006-10-17 US claimed
EP-1115695-A1 (R)-CHIRAL HALOGENATED 1-SUBSTITUTEDAMINO-(N+1)-ALKANOLS USEFUL FOR INHIBITING CHOLESTERYL ESTER TRANSFER PROTEIN ACTIVITY Monsanto Company (US) 2001-07-18 EP claimed
WO-2000078795-A2 RUFOMYCINS AND DERIVATIVES THEREOF USEFUL AS INHIBITORS OF MULTI-DRUG RESISTANCE ASSOCIATED PROTEIN-1 (MRP-1) ELI LILLY AND COMPANY (US) 2000-12-28 WO claimed
WO-2000018723-A1 SUBSTITUTED N-ALIPHATIC-N-AROMATIC TERTIARY-HETEROALKYLAMINES USEFUL FOR INHIBITING CHOLESTERYL ESTER TRANSFER PROTEIN ACTIVITY MONSANTO COMPANY (US) 2000-04-06 WO claimed
WO-2000018724-A1 (R)-CHIRAL HALOGENATED 1-SUBSTITUTEDAMINO-(n+1)-ALKANOLS USEFUL FOR INHIBITING CHOLESTERYL ESTER TRANSFER PROTEIN ACTIVITY MONSANTO COMPANY (US) 2000-04-06 WO claimed
WO-2000018721-A1 SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL TERTIARY-HETEROALKYLAMINES USEFUL FOR INHIBITING CHOLESTERYL ESTER TRANSFER PROTEIN ACTIVITY MONSANTO COMPANY (US) 2000-04-06 WO claimed
EP-0256537-B1 COLOR PRINT AND A METHOD FOR PRODUCING THE SAME FUJI PHOTO FILM CO., LTD. (JP) 1992-12-30 EP claimed
US-4857444-A PHOTOSTABILITY, DISCOLORATION INHIBITION FUJI PHOTO FILM CO., LTD. (JP) 1989-08-15 US claimed
EP-0320753-A2 Derivatives of cyclic aminoacids, their preparation, compounds containing them, and their use HOECHST AKTIENGESELLSCHAFT (DE) 1989-06-21 EP claimed
EP-0286927-A2 Pyrrolidine-2-(1,3-dicarbonyl) derivatives, process for their preparation, agents containing them as well as their use HOECHST AKTIENGESELLSCHAFT (DE) 1988-10-19 EP claimed
EP-0256537-A2 Color print and a method for producing the same FUJI PHOTO FILM CO., LTD. (JP) 1988-02-24 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140275069-A1 Novel inhibitor compounds of phosphodiesterase type 10A PDE5A, PDE3A, PDE3B ALDH1A1 743/4885CYP1A1 83/4885CYP1B1 67/4885
US-20100130784-A1 SUBSTITUTED 1,1,1-TRIFLUORO-3-[(BENZYL)-(PYRIMIDIN-2-YL)-AMINO]-PROPAN-2-OL COMPOUNDS APOB, LDLR, HDLBP ALDH1A1 1173/4885CYP1A1 648/4885CYP1B1 749/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.