Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 3/20 | 0.49 |
| ▸ | RXRB | P28702 | 2/20 | 0.49 |
| ▸ | RXRG | P48443 | 2/20 | 0.49 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | PLG | P00747 | 1/20 | 0.42 |
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
| ▸ | PLAT | P00750 | 1/20 | 0.42 |
| ▸ | RARB | P10826 | 2/20 | 0.42 |
| ▸ | RARA | P10276 | 1/20 | 0.42 |
| ▸ | RARG | P13631 | 1/20 | 0.42 |
| ▸ | MYC | P01106 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31371666 | 0.85 | SLC16A3 (0.47) | SLC16A3ALDH1A1KDM4EMYCHPGD | |
| SCHEMBL19454401 | 0.83 | KMT2A (0.42) | RXRARXRBRXRGSLC16A3ALDH1A1 | |
| SCHEMBL24849607 | 0.82 | KMT2A (0.59) | RXRARXRBRXRGALDH1A1KDM4E | |
| SCHEMBL8646935 | 0.82 | SLC16A3 (0.51) | SLC16A3ALDH1A1KDM4EMYCHPGD | |
| SCHEMBL7688037 | 0.81 | RXRA (0.44) | RXRARXRBRXRGALDH1A1MAPT | |
| SCHEMBL1110796 | 0.80 | CA12 (0.43) | ALDH1A1KDM4EHPGDMAPTNPC1 | |
| SCHEMBL10606874 | 0.80 | SLC16A3 (0.50) | SLC16A3ALDH1A1KDM4EMYCHPGD | |
| SCHEMBL2434816 | 0.80 | RXRA (0.43) | RXRARXRBRXRGALDH1A1KDM4E | |
| SCHEMBL25217340 | 0.79 | KLKB1 (0.45) | ALDH1A1KDM4EMAPTNPC1MEN1 | |
| SCHEMBL352720 | 0.78 | SLC16A3 (0.49) | RXRARXRBSLC16A3ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230026271-A1 | Piperazine Compounds for Inhibiting CPS1 | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2023-01-26 | — | — | US | disclosed |
| EP-4061803-A1 | PIPERAZINE COMPOUNDS FOR INHIBITING CPS1 | Eisai R&D Management Co., Ltd. (JP) | 2022-09-28 | — | — | EP | disclosed |
| CN-114981247-A | Piperazine compounds for inhibiting CPS1 | 卫材R&D管理有限公司 | 2022-08-30 | — | — | CN | disclosed |
| WO-2021102300-A1 | PIPERAZINE COMPOUNDS FOR INHIBITING CPS1 | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2021-05-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230026271-A1 | Piperazine Compounds for Inhibiting CPS1 | CPS1, CPSF1, CPSF7 | RXRA 3267/4885RXRB 3139/4885RXRG 3208/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.