Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | USP2 | O75604 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 5/20 | 0.34 |
| ▸ | CSF1R | P07333 | 2/20 | 0.34 |
| ▸ | USP1 | O94782 | 3/20 | 0.34 |
| ▸ | WDR48 | Q8TAF3 | 3/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23397083 | 0.80 | CYP1A2 (0.35) | NR1H4LMNACYP1A2CYP3A4HSD17B10 | |
| SCHEMBL23396652 | 0.79 | NR1H4 (0.38) | NR1H4LMNACYP1A2CYP3A4HSD17B10 | |
| SCHEMBL18742928 | 0.77 | WNT3A (0.57) | MAPK1 | |
| SCHEMBL23396844 | 0.73 | USP1 (0.50) | NR1H4CYP3A4CYP2D6USP1WDR48 | |
| SCHEMBL23396687 | 0.72 | NR1H4 (0.38) | NR1H4LMNACYP1A2CYP3A4HSD17B10 | |
| SCHEMBL23396744 | 0.70 | AR (0.48) | LMNACYP1A2CYP3A4HSD17B10USP2 | |
| SCHEMBL23396735 | 0.70 | EGFR (0.33) | NR1H4LMNACYP1A2CYP3A4HSD17B10 | |
| SCHEMBL23397008 | 0.70 | HDAC6 (0.37) | LMNACYP1A2CYP3A4HSD17B10USP2 | |
| SCHEMBL18703773 | 0.68 | WNT3A (0.56) | MAPK1 | |
| SCHEMBL18742876 | 0.68 | MAPK9 (0.49) | NR1H4LMNACYP1A2CYP3A4HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3359154-B1 | WNT SIGNALING PATHWAY INHIBITORS AND THERAPEUTIC APPLICATIONS THEREOF | Suzhou Yunxuan Yiyao Keji Youxian Gongsi (CN) | 2021-05-26 | — | — | EP | disclosed |