Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | BRAF | P15056 | 1/20 | 0.46 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.46 |
| ▸ | PRKDC | P78527 | 1/20 | 0.46 |
| ▸ | ATR | Q13535 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | NEK2 | P51955 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2271725 | 0.92 | SYK (0.71) | SYKCYP2C9MAPTPOLBATM | |
| SCHEMBL2347258 | 0.82 | SYK (0.58) | SYKCYP2C9MAPTKDM4ELMNA | |
| SCHEMBL2338325 | 0.81 | SYK (0.61) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL2345280 | 0.79 | SYK (0.56) | SYKCYP2C9MAPTPOLBATM | |
| SCHEMBL2275541 | 0.78 | SYK (0.68) | SYKCYP2C9MAPTPOLBATM | |
| SCHEMBL2345330 | 0.77 | SYK (0.56) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL2277066 | 0.77 | SYK (0.67) | SYKCYP2C9ATMJAK2JAK1 | |
| SCHEMBL2277878 | 0.76 | SYK (0.76) | SYKCYP2C9MAPTKDM4ELMNA | |
| SCHEMBL2279926 | 0.76 | SYK (0.76) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL27822558 | 0.76 | SYK (0.66) | SYKCYP2C9JAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245033-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-08-31 | — | — | EP | disclosed |