Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.44 |
| ▸ | NEK2 | P51955 | 5/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.43 |
| ▸ | CASR | P41180 | 1/20 | 0.41 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2278290 | 0.92 | SYK (0.69) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL2340338 | 0.82 | SYK (0.60) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL2338325 | 0.79 | SYK (0.61) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL2277584 | 0.79 | SYK (0.78) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL2275541 | 0.76 | SYK (0.68) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL2345330 | 0.75 | SYK (0.56) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL2277066 | 0.75 | SYK (0.67) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL2277878 | 0.75 | SYK (0.76) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL2271725 | 0.74 | SYK (0.71) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL27822558 | 0.74 | SYK (0.66) | SYKCYP2C9JAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245033-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-08-31 | — | — | EP | disclosed |