⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23405208 | 0.81 | ADORA3 (0.33) | — | |
| SCHEMBL23430004 | 0.81 | ADORA3 (0.33) | — | |
| SCHEMBL31350170 | 0.77 | HRH2 (0.43) | — | |
| SCHEMBL31350094 | 0.76 | HRH2 (0.34) | — | |
| SCHEMBL31350143 | 0.75 | ADORA3 (0.38) | — | |
| SCHEMBL21685924 | 0.72 | PRMT5 (0.32) | — | |
| SCHEMBL21683387 | 0.72 | PRMT5 (0.32) | — | |
| SCHEMBL23429993 | 0.72 | — | — | |
| SCHEMBL23405284 | 0.72 | — | — | |
| SCHEMBL23429861 | 0.72 | HRH2 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11952380-B2 | Substituted bicyclic heterocyclic compounds as PRMT5 inhibitors | LUPIN LIMITED (IN) | 2024-04-09 | — | — | US | disclosed |
| US-11459330-B2 | Substituted bicyclic heterocyclic compounds as PRMT5 inhibitors | LUPIN LIMITED (IN) | 2022-10-04 | — | — | US | disclosed |
| US-20220267339-A1 | SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS | LUPIN LIMITED (IN) | 2022-08-25 | — | — | US | disclosed |
| US-20210163486-A1 | SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS | LUPIN LIMITED (IN) | 2021-06-03 | — | — | US | disclosed |