Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29743805 | 1.00 | CYP2A6 (0.55) | CYP2A6LMNAHIF1AROCK2ROCK1 | |
| SCHEMBL29744073 | 0.88 | F2 (0.58) | NPC1RAB9AMEN1KMT2A | |
| SCHEMBL20641503 | 0.88 | F2 (0.58) | NPC1RAB9AMEN1KMT2A | |
| SCHEMBL23406002 | 0.87 | TRPV1 (0.52) | KCNK3HTTHSD17B10RAB9AKDM4E | |
| SCHEMBL29743862 | 0.87 | TRPV1 (0.52) | KCNK3HTTHSD17B10RAB9AKDM4E | |
| SCHEMBL6643666 | 0.85 | LMNA (0.67) | LMNAHIF1AROCK2ROCK1HDAC1 | |
| SCHEMBL23406055 | 0.85 | SMN1; SMN2 (0.65) | CYP2A6LMNAHIF1AALOX15NPC1 | |
| SCHEMBL23406114 | 0.82 | GRM5 (0.54) | LMNAHDAC1HDAC3HDAC2KCNK3 | |
| SCHEMBL29744091 | 0.82 | GRM5 (0.54) | LMNAHDAC1HDAC3HDAC2KCNK3 | |
| SCHEMBL23406009 | 0.82 | GRM1 (0.57) | HTTNPC1RAB9ASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11377436-B2 | EAAT2 enhancing molecules | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2022-07-05 | — | — | US | disclosed |
| US-11377436-B2 | EAAT2 enhancing molecules | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2022-07-05 | — | — | US | disclosed |
| US-20210163440-A1 | EAAT2 ENHANCING MOLECULES | BRIGHAM & WOMENS HOSPITAL INC (US) | 2021-06-03 | — | — | US | disclosed |
| US-20210163440-A1 | EAAT2 ENHANCING MOLECULES | BRIGHAM & WOMENS HOSPITAL INC (US) | 2021-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210163440-A1 | EAAT2 ENHANCING MOLECULES | SLC1A2, SLC1A1, SLC1A3 | CYP2A6 3042/4885LMNA 4504/4885HIF1A 1257/4885 |
| US-11377436-B2 | EAAT2 enhancing molecules | SLC1A2, SLC1A1, SLC1A3 | CYP2A6 3042/4885LMNA 4504/4885HIF1A 1257/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.