Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.67 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.65 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.65 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.62 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.58 |
| ▸ | THRB | P10828 | 1/20 | 0.57 |
| ▸ | PIM1 | P11309 | 1/20 | 0.56 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.56 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11591993 | 0.90 | LMNA (0.63) | LMNAHIF1AROCK2ROCK1HDAC1 | |
| SCHEMBL11591966 | 0.87 | LMNA (0.69) | LMNAHIF1AROCK2ROCK1HDAC1 | |
| SCHEMBL23406076 | 0.85 | CYP2A6 (0.55) | LMNAHIF1AROCK2ROCK1HDAC1 | |
| SCHEMBL29743805 | 0.85 | CYP2A6 (0.55) | LMNAHIF1AROCK2ROCK1HDAC1 | |
| SCHEMBL20771043 | 0.83 | SMN1; SMN2 (0.57) | LMNAHIF1AROCK2ROCK1HDAC1 | |
| SCHEMBL23015840 | 0.83 | TDP1 (0.56) | LMNAHIF1AROCK2ROCK1HDAC1 | |
| SCHEMBL6646471 | 0.81 | RAB9A (0.70) | LMNAHIF1AROCK2ROCK1HDAC1 | |
| SCHEMBL31414959 | 0.81 | RAB9A (0.70) | LMNAHIF1AROCK2ROCK1HDAC1 | |
| SCHEMBL29199014 | 0.81 | LMNA (0.56) | LMNAHIF1AROCK2ROCK1HDAC1 | |
| SCHEMBL997872 | 0.81 | RAB9A (0.59) | HTTKCNK3NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016102969-A1 | INHIBITION OF HAIR GROWTH | THE UNIVERSITY OF MANCHESTER (GB) | 2016-06-30 | — | — | WO | claimed |
| EP-1453831-A1 | 1H-PYRROLO(3,2-B)PYRIDINE-3-CARBOXYLIC ACID AMIDES | Neurogen Corporation (US) | 2004-09-08 | — | — | EP | claimed |
| WO-2003044018-A1 | 1H-PYRROLO[3,2-B]PYRIDINE-3-CARBOXYLIC ACID AMIDES | NEUROGEN CORPORATION (US) | 2003-05-30 | — | — | WO | claimed |
| WO-2016102969-A1 | INHIBITION OF HAIR GROWTH | THE UNIVERSITY OF MANCHESTER (GB) | 2016-06-30 | — | — | WO | disclosed |