Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KDM4A | O75164 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | REN | P00797 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28668028 | 0.82 | TTR (0.39) | KDM4ESMN1; SMN2POLBKMT2ACYP2D6 | |
| SCHEMBL1573467 | 0.78 | ADRA2A (0.38) | KDM4ESMN1; SMN2KMT2ACYP2D6ALDH1A1 | |
| Hydrochloric Acid SCHEMBL28364110 | 0.75 | SMN1; SMN2 (0.44) | KDM4ESMN1; SMN2KMT2AALDH1A1 | |
| Bromide SCHEMBL28364106 | 0.75 | SMN1; SMN2 (0.41) | KDM4ESMN1; SMN2KMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL29054527 | 0.75 | KDM4E (0.65) | KDM4ESMN1; SMN2KMT2ACYP2D6ALDH1A1 | |
| SCHEMBL27625281 | 0.73 | SMN1; SMN2 (0.43) | KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL4669258 | 0.73 | KMT2A (0.48) | KDM4ESMN1; SMN2KMT2ACYP2D6ALDH1A1 | |
| SCHEMBL1740334 | 0.71 | SMN1; SMN2 (0.41) | KDM4ESMN1; SMN2KMT2A | |
| SCHEMBL698829 | 0.70 | NPC1 (0.39) | KDM4ESMN1; SMN2KMT2ACYP2D6CYP1A2 | |
| SCHEMBL27750528 | 0.70 | KDM4E (0.46) | KDM4ESMN1; SMN2POLBKMT2ACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4737444-A1 | PROCESSES AND INTERMEDIATES FOR PREPARING MCL1 INHIBITORS | Gilead Sciences, Inc. (US) | 2026-05-06 | — | — | EP | disclosed |
| US-12410146-B2 | Processes and intermediates for preparing MCL1 inhibitors | GILEAD SCIENCES, INC. (US) | 2025-09-09 | — | — | US | disclosed |
| EP-4484435-A2 | PROCESSES AND INTERMEDIATES FOR PREPARING MCL1 INHIBITORS | Gilead Sciences, Inc. (US) | 2025-01-01 | — | — | EP | disclosed |
| EP-4065567-B1 | PROCESSES AND INTERMEDIATES FOR PREPARING MCL1 INHIBITORS | GILEAD SCIENCES INC (US) | 2024-09-11 | — | — | EP | disclosed |
| US-20240109851-A1 | PROCESSES AND INTERMEDIATES FOR PREPARING MCL1 INHIBITORS | GILEAD SCIENCES, INC. | 2024-04-04 | — | — | US | disclosed |
| US-11760736-B2 | Processes and intermediates for preparing MCL1 inhibitors | GILEAD SCIENCES, INC. (US) | 2023-09-19 | — | — | US | disclosed |
| US-20230013713-A1 | PROCESSES AND INTERMEDIATES FOR PREPARING MCL1 INHIBITORS | GILEAD SCIENCES, INC. | 2023-01-19 | — | — | US | disclosed |
| EP-4065567-A1 | PROCESSES AND INTERMEDIATES FOR PREPARING MCL1 INHIBITORS | GILEAD SCIENCES, INC. (US) | 2022-10-05 | — | — | EP | disclosed |
| US-11325891-B2 | Processes and intermediates for preparing MCL1 inhibitors | GILEAD SCIENCES, INC. (US) | 2022-05-10 | — | — | US | disclosed |
| US-20210179570-A1 | PROCESSES AND INTERMEDIATES FOR PREPARING MCL1 INHIBITORS | GILEAD SCIENCES, INC. | 2021-06-17 | — | — | US | disclosed |
| WO-2021108254-A1 | PROCESSES AND INTERMEDIATES FOR PREPARING MCL1 INHIBITORS | GILEAD SCIENCES, INC. (US) | 2021-06-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12410146-B2 | Processes and intermediates for preparing MCL1 inhibitors | MCL1, BAK1, BCL3 | KDM4E 1483/4885SMN1; SMN2 1917/4885POLB 935/4885 |
| US-11760736-B2 | Processes and intermediates for preparing MCL1 inhibitors | MCL1, BAK1, BCL3 | KDM4E 1483/4885SMN1; SMN2 1917/4885POLB 935/4885 |
| US-20210179570-A1 | PROCESSES AND INTERMEDIATES FOR PREPARING MCL1 INHIBITORS | MCL1, BAK1, BCL3 | KDM4E 1483/4885SMN1; SMN2 1917/4885POLB 935/4885 |
| US-11325891-B2 | Processes and intermediates for preparing MCL1 inhibitors | MCL1, BAK1, BCL3 | KDM4E 1483/4885SMN1; SMN2 1917/4885POLB 935/4885 |
| US-20240109851-A1 | PROCESSES AND INTERMEDIATES FOR PREPARING MCL1 INHIBITORS | MCL1, BAK1, BCL3 | KDM4E 1483/4885SMN1; SMN2 1917/4885POLB 935/4885 |
| US-20230013713-A1 | PROCESSES AND INTERMEDIATES FOR PREPARING MCL1 INHIBITORS | MCL1, BAK1, BCL3 | KDM4E 1483/4885SMN1; SMN2 1917/4885POLB 935/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.