Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | PRKCA | P17252 | 1/20 | 0.37 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL698625 | 0.88 | MEN1 (0.37) | NPC1SMN1; SMN2KMT2A | |
| SCHEMBL697750 | 0.87 | POLB (0.36) | NPC1SMN1; SMN2CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL27845586 | 0.85 | ADRA1D (0.36) | SMN1; SMN2CYP1A2CYP2D6CYP2C19PRKCA | |
| SCHEMBL1573126 | 0.85 | ALDH1A1 (0.40) | NPC1KDM4E | |
| Ethane SCHEMBL27845734 | 0.84 | ADRA1D (0.36) | SMN1; SMN2CYP1A2CYP2D6CYP2C19PRKCA | |
| SCHEMBL697333 | 0.83 | KMT2A (0.36) | NPC1SMN1; SMN2KDM4EKMT2A | |
| SCHEMBL702874 | 0.82 | KMT2A (0.36) | NPC1KMT2ATDP1 | |
| SCHEMBL3528743 | 0.81 | ALDH1A1 (0.35) | NPC1SMN1; SMN2KDM4ECYP1A2CYP2D6 | |
| SCHEMBL698624 | 0.81 | ALDH1A1 (0.35) | NPC1SMN1; SMN2KDM4ECYP1A2CYP2D6 | |
| SCHEMBL697152 | 0.81 | ALDH1A1 (0.35) | NPC1SMN1; SMN2KDM4ECYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2423199-A1 | Substituted imidazoles and their use as pesticides | Pfizer Limited (GB) | 2012-02-29 | — | — | EP | disclosed |
| EP-1981853-B1 | SUBSTITUTED IMIDAZOLES AND THEIR USE AS PESTICIDES | PFIZER LTD (GB) | 2011-04-13 | — | — | EP | disclosed |