Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 9/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.52 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | KLKB1 | P03952 | 4/20 | 0.36 |
| ▸ | F2 | P00734 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | YWHAG | P61981 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | METAP1 | P53582 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23409674 | 0.88 | TGFBR1 (0.56) | TGFBR1MAPK14AURKAAURKBALOX15 | |
| SCHEMBL29959677 | 0.88 | TGFBR1 (0.56) | TGFBR1MAPK14AURKAAURKBALOX15 | |
| SCHEMBL31519383 | 0.88 | TGFBR1 (0.61) | TGFBR1MAPK14AURKAAURKBALOX15 | |
| SCHEMBL29959955 | 0.88 | TGFBR1 (0.51) | TGFBR1MAPK14AURKAAURKBKLKB1 | |
| Hydrochloric Acid SCHEMBL23409670 | 0.87 | TGFBR1 (0.60) | TGFBR1MAPK14AURKAAURKBALOX15 | |
| SCHEMBL23409664 | 0.87 | TGFBR1 (0.59) | TGFBR1MAPK14AURKAAURKBALOX15 | |
| SCHEMBL29959820 | 0.87 | TGFBR1 (0.59) | TGFBR1MAPK14AURKAAURKBALOX15 | |
| SCHEMBL28822071 | 0.86 | TGFBR1 (0.69) | TGFBR1MAPK14AURKAAURKBTSHR | |
| SCHEMBL23409949 | 0.86 | TGFBR1 (0.56) | TGFBR1MAPK14KLKB1ALDH1A1 | |
| SCHEMBL23409951 | 0.85 | TGFBR1 (0.59) | TGFBR1MAPK14AURKAAURKBALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12297186-B2 | Benzylamide derivatives as inhibitors of transforming growth factor-beta receptor I/ALK5 | Agomab Spain, S.L.U. (ES) | 2025-05-13 | — | — | US | disclosed |
| CN-114787145-B | Benzamide derivatives as transforming growth factor-beta receptor I/ALK5 inhibitors | 阿戈麦布西班牙股份有限公司 | 2024-03-26 | — | — | CN | disclosed |
| US-20230025933-A1 | Benzylamide Derivatives as Inhibitors of Transforming Growth Factor-Beta Receptor I/Alk5 | Agomab Spain, S.L.U. (ES) | 2023-01-26 | — | — | US | disclosed |
| EP-4065572-A1 | BENZYLAMIDE DERIVATIVES AS INHIBITORS OF TRANSFORMING GROWTH FACTOR-BETA RECEPTOR I/ALK5 | Origo Biopharma, S.L. (ES) | 2022-10-05 | — | — | EP | disclosed |
| CN-114787145-A | Benzamide derivatives as transforming growth factor-beta receptor I/ALK5 inhibitors | 奥里戈生物制药有限公司 | 2022-07-22 | — | — | CN | disclosed |
| WO-2021105317-A1 | BENZYLAMIDE DERIVATIVES AS INHIBITORS OF TRANSFORMING GROWTH FACTOR-BETA RECEPTOR I/ALK5 | ORIGO BIOPHARMA, S.L. (ES) | 2021-06-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12297186-B2 | Benzylamide derivatives as inhibitors of transforming growth factor-beta receptor I/ALK5 | TGFBR2, TGFBR1, ACVR1 | TGFBR1 2/4885MAPK14 1610/4885AAK1 2457/4885 |
| US-20230025933-A1 | Benzylamide Derivatives as Inhibitors of Transforming Growth Factor-Beta Receptor I/Alk5 | TGFBR2, TGFBR1, ACVR1 | TGFBR1 2/4885MAPK14 1610/4885AAK1 2457/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.