Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 6/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | METAP1 | P53582 | 1/20 | 0.37 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23409671 | 0.88 | TGFBR1 (0.52) | TGFBR1MAPK14ALDH1A1AURKAAURKB | |
| SCHEMBL23409949 | 0.86 | TGFBR1 (0.56) | TGFBR1MAPK14ALDH1A1LMNAKLKB1 | |
| SCHEMBL31519383 | 0.86 | TGFBR1 (0.61) | TGFBR1MAPK14ALDH1A1AURKAAURKB | |
| Hydrochloric Acid SCHEMBL23409670 | 0.85 | TGFBR1 (0.60) | TGFBR1MAPK14AURKAAURKB | |
| SCHEMBL29959820 | 0.85 | TGFBR1 (0.59) | TGFBR1MAPK14LMNAMAPTAURKA | |
| SCHEMBL23409664 | 0.85 | TGFBR1 (0.59) | TGFBR1MAPK14LMNAMAPTAURKA | |
| SCHEMBL28822071 | 0.85 | TGFBR1 (0.69) | TGFBR1MAPK14ALDH1A1LMNAAURKA | |
| SCHEMBL23409951 | 0.84 | TGFBR1 (0.59) | TGFBR1MAPK14ALDH1A1LMNAAURKA | |
| SCHEMBL28822090 | 0.84 | TGFBR1 (0.62) | TGFBR1MAPK14ALDH1A1LMNAMAPT | |
| SCHEMBL28822077 | 0.84 | TGFBR1 (0.59) | TGFBR1MAPK14LMNAMAPTKLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4065572-A1 | BENZYLAMIDE DERIVATIVES AS INHIBITORS OF TRANSFORMING GROWTH FACTOR-BETA RECEPTOR I/ALK5 | Origo Biopharma, S.L. (ES) | 2022-10-05 | — | — | EP | disclosed |