Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 3/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | STK17B | O94768 | 1/20 | 0.33 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20802511 | 0.85 | ESR1 (0.39) | ESR1ESR2DHFRPPARGMEN1 | |
| SCHEMBL4369960 | 0.84 | ESR1 (0.41) | ESR1ESR2DHFRIDO1MEN1 | |
| SCHEMBL12243808 | 0.82 | ESR1 (0.40) | ESR1ESR2TSHRHRH3DHFR | |
| SCHEMBL20332457 | 0.81 | ESR1 (0.42) | ESR1ESR2DHFRPPARGMEN1 | |
| SCHEMBL828068 | 0.79 | GABRP (0.40) | ESR1ESR2TSHRTDP1IDO1 | |
| SCHEMBL20332789 | 0.78 | L3MBTL1 (0.39) | ESR1ESR2PPARGMEN1LMNA | |
| SCHEMBL19107508 | 0.78 | ESR1 (0.37) | ESR1ESR2DHFRPPARGMEN1 | |
| SCHEMBL2604908 | 0.78 | ESR1 (0.42) | ESR1ESR2HRH3IDO1MEN1 | |
| SCHEMBL23206735 | 0.77 | KCNH2 (0.46) | ESR1ESR2TDP1MEN1KMT2A | |
| SCHEMBL24067622 | 0.77 | MEN1 (0.37) | ESR1ESR2PPARGMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021102332-A1 | TGFBETAR2 INHIBITOR-LRRC15 ANTIBODY CONJUGATES AND USES THEREOF | SILVERBACK THERAPEUTICS, INC. (US) | 2021-05-27 | — | — | WO | disclosed |