SCHEMBL2342015

SCHEMBL2342015

COC(=O)c1cc(N)cc(C(F)(F)F)n1

nearest known ligand 0.46

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
NQO2 P16083 5/20 0.46
CFTR P13569 2/20 0.45
MAPT P10636 4/20 0.41
KDM4E B2RXH2 3/20 0.40
ALDH1A1 P00352 3/20 0.40
HPGD P15428 1/20 0.40
SDHB P21912 2/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
TP53 P04637 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
P2RX7 Q99572 1/20 0.40
NOTUM Q6P988 1/20 0.40
HSP90AA1 P07900 1/20 0.39
HSP90AB1 P08238 1/20 0.39
PKM P14618 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29882458 0.83 KDM4E (0.47) MAPTKDM4EALDH1A1HPGDSMN1; SMN2
SCHEMBL23580468 0.83 KDM4E (0.47) MAPTKDM4EALDH1A1HPGDSMN1; SMN2
SCHEMBL2013927 0.82 NQO2 (0.55) NQO2MAPTKDM4EALDH1A1HPGD
SCHEMBL21199850 0.82 SMN1; SMN2 (0.43) CFTRMAPTKDM4EALDH1A1HPGD
SCHEMBL18839634 0.81 HSP90AA1 (0.42) KDM4EALDH1A1HPGDSMN1; SMN2TP53
SCHEMBL29882592 0.81 HSP90AA1 (0.42) KDM4EALDH1A1HPGDSMN1; SMN2TP53
SCHEMBL21200024 0.81 ALDH1A1 (0.44) MAPTKDM4EALDH1A1HPGDSMN1; SMN2
SCHEMBL21199812 0.81 NOTUM (0.54) CFTRMAPTKDM4EALDH1A1HPGD
SCHEMBL2340704 0.81 MAPT (0.52) NQO2CFTRMAPTKDM4EALDH1A1
SCHEMBL31574177 0.81 MAPT (0.52) NQO2CFTRMAPTKDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1498413-B1 4-Aminopicolinates and their use as herbicides DOW AGROSCIENCES LLC (US) 2011-08-31 EP disclosed
EP-1246802-B1 4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2007-03-14 EP disclosed
EP-1498413-A1 4-Aminopicolinates and their use as herbicides Dow AgroSciences LLC (US) 2005-01-19 EP disclosed
EP-1246802-A1 4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES Dow Agrosciences LLC (US) 2002-10-09 EP disclosed
US-20010047099-A1 4-aminopicolinates and their use as herbicides DOW AGROSCIENCES LLC 2001-11-29 US disclosed
US-6297197-B1 DEMONSTRATING A BROAD SPECTRUM OF WEED CONTROL. DOW AGROSCIENCES LLC 2001-10-02 US disclosed
WO-2001051468-A1 4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2001-07-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20010047099-A1 4-aminopicolinates and their use as herbicides AADAT, ABAT, DDT NQO2 1035/4885CFTR 3768/4885MAPT 437/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.