Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LGALS8 | O00214 | 2/20 | 0.53 |
| ▸ | LGALS3 | P17931 | 2/20 | 0.53 |
| ▸ | LGALS4 | P56470 | 2/20 | 0.53 |
| ▸ | CA12 | O43570 | 8/20 | 0.50 |
| ▸ | CA1 | P00915 | 8/20 | 0.50 |
| ▸ | CA2 | P00918 | 8/20 | 0.50 |
| ▸ | CA9 | Q16790 | 8/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 8/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.47 |
| ▸ | PYGB | P11216 | 1/20 | 0.47 |
| ▸ | AMY2A | P04746 | 1/20 | 0.46 |
| ▸ | FGF1 | P05230 | 1/20 | 0.45 |
| ▸ | FGF2 | P09038 | 1/20 | 0.45 |
| ▸ | VEGFA | P15692 | 1/20 | 0.45 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.45 |
| ▸ | TYR | P14679 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16217741 | 1.00 | LGALS8 (0.53) | LGALS8LGALS3LGALS4CA12CA1 | |
| SCHEMBL21894588 | 1.00 | LGALS8 (0.53) | LGALS8LGALS3LGALS4CA12CA1 | |
| SCHEMBL23617758 | 1.00 | LGALS8 (0.53) | LGALS8LGALS3LGALS4CA12CA1 | |
| SCHEMBL22296782 | 1.00 | LGALS8 (0.53) | LGALS8LGALS3LGALS4CA12CA1 | |
| SCHEMBL23735640 | 1.00 | LGALS8 (0.53) | LGALS8LGALS3LGALS4CA12CA1 | |
| SCHEMBL21698210 | 1.00 | LGALS8 (0.53) | LGALS8LGALS3LGALS4CA12CA1 | |
| SCHEMBL18976778 | 0.90 | MEN1 (0.49) | LGALS8LGALS3LGALS4MEN1KMT2A | |
| SCHEMBL22296747 | 0.87 | MEN1 (0.45) | LGALS8LGALS3LGALS4CA12CA1 | |
| SCHEMBL16221568 | 0.86 | LGALS8 (0.51) | LGALS8LGALS3LGALS4CA12CA1 | |
| SCHEMBL22372512 | 0.85 | LGALS8 (0.56) | LGALS8LGALS3LGALS4CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3828275-A1 | COMPOSITIONS AND METHODS FOR MODULATING TTR EXPRESSION | Ionis Pharmaceuticals, Inc. (US) | 2021-06-02 | — | — | EP | disclosed |