Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 12/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.42 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.40 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.39 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL835796 | 0.85 | FYN (0.54) | FYNDYRK3CCNT1CCNA2CDK2 | |
| SCHEMBL836898 | 0.78 | FGFR3 (0.67) | FYNFGFR1FGFR3TBK1IKBKE | |
| SCHEMBL835778 | 0.76 | FYN (0.47) | FYNFGFR1FGFR3TBK1IKBKE | |
| SCHEMBL837456 | 0.75 | GABRG2 (0.44) | FYNFGFR1FGFR3TBK1DYRK3 | |
| SCHEMBL837388 | 0.74 | GRM5 (0.45) | FYNFGFR1FGFR3TBK1DYRK1A | |
| SCHEMBL836396 | 0.74 | FGFR1 (0.43) | FGFR1FGFR3TBK1DYRK3CCNT1 | |
| SCHEMBL834911 | 0.73 | FYN (0.49) | FYNFGFR1FGFR3TBK1 | |
| SCHEMBL836098 | 0.72 | FGFR3 (0.39) | FGFR1FGFR3TBK1DYRK1AIKBKE | |
| SCHEMBL3029778 | 0.67 | FGFR3 (0.50) | FYNFGFR1FGFR3TBK1IKBKE | |
| SCHEMBL3658714 | 0.67 | KDR (0.45) | FGFR3TBK1CDK2DYRK1AIKBKE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2183027-B1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2011-08-31 | — | — | EP | claimed |