Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 9/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.50 |
| ▸ | KDR | P35968 | 9/20 | 0.48 |
| ▸ | FYN | P06241 | 4/20 | 0.48 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.44 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL836898 | 0.88 | FGFR3 (0.67) | FGFR3FGFR1FYNPI4KBTBK1 | |
| SCHEMBL3031154 | 0.87 | FYN (0.52) | FGFR3KDRFYN | |
| SCHEMBL3031024 | 0.84 | KDR (0.46) | FGFR3KDRFLT3 | |
| SCHEMBL3020724 | 0.83 | KDR (0.51) | FGFR3KDRTBK1 | |
| SCHEMBL13336647 | 0.83 | KDR (0.65) | FGFR3FGFR1KDRFYNFLT3 | |
| SCHEMBL3025677 | 0.82 | KDR (0.48) | FGFR3KDRFYNTBK1IKBKE | |
| SCHEMBL3030841 | 0.81 | ATM (0.57) | FGFR3FGFR1KDRFYNFLT3 | |
| SCHEMBL3025497 | 0.81 | FYN (0.53) | FGFR3KDRFYN | |
| SCHEMBL3029705 | 0.80 | KDR (0.65) | FGFR3KDRTBK1FLT3 | |
| SCHEMBL3033485 | 0.80 | FGFR3 (0.56) | FGFR3FGFR1KDRFYNFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101827844-B | Imidazo [1,2-a] pyridine derivatives useful as ALK inhibitors | NOVARTIS AG | 2013-08-14 | — | — | CN | claimed |
| EP-2212323-B1 | IMIDAZO [1,2-A] PYRIDINE DERIVATIVES USEFUL AS ALK INHIBITORS | NOVARTIS AG (CH) | 2012-08-15 | — | — | EP | claimed |
| CN-101827844-B | Imidazo [1,2-a] pyridine derivatives useful as ALK inhibitors | NOVARTIS AG | 2013-08-14 | — | — | CN | disclosed |
| US-8367662-B2 | Organic compounds | NOVARTIS AG (CH) | 2013-02-05 | — | — | US | disclosed |
| EP-2212323-B1 | IMIDAZO [1,2-A] PYRIDINE DERIVATIVES USEFUL AS ALK INHIBITORS | NOVARTIS AG (CH) | 2012-08-15 | — | — | EP | disclosed |
| CN-101827844-A | Imidazo [1,2-a] pyridine derivatives useful as ALK inhibitors | NOVARTIS AG | 2010-09-08 | — | — | CN | disclosed |
| US-20100210641-A1 | Organic Compounds | NOVARTIS AG (CH) | 2010-08-19 | — | — | US | disclosed |
| EP-2212323-A2 | IMIDAZO [1,2-A] PYRIDINE DERIVATIVES USEFUL AS ALK INHIBITORS | Novartis AG (CH) | 2010-08-04 | — | — | EP | disclosed |
| WO-2009050183-A2 | IMIDAZO [1, 2-A] PYRIDINE DERIVATIVES USEFUL AS ALK INHIBITORS | NOVARTIS AG (CH) | 2009-04-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100210641-A1 | Organic Compounds | ALK, ACVR1, ACVRL1 | FGFR3 32/4885FGFR1 72/4885KDR 372/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.