Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 5/20 | 1.00 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.63 |
| ▸ | BRD4 | O60885 | 1/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12196136 | 1.00 | EPHX1 (1.00) | EPHX1EPHX2ALDH1A1BRD4L3MBTL1 | |
| SCHEMBL23432014 | 1.00 | EPHX1 (1.00) | EPHX1EPHX2ALDH1A1BRD4L3MBTL1 | |
| SCHEMBL9178993 | 0.92 | EPHX1 (0.84) | EPHX1EPHX2ALDH1A1BRD4L3MBTL1 | |
| SCHEMBL8600781 | 0.84 | EPHX1 (0.73) | EPHX1EPHX2ALDH1A1BRD4L3MBTL1 | |
| SCHEMBL5640619 | 0.84 | EPHX1 (0.73) | EPHX1EPHX2RAB9ANPC1ROCK2 | |
| SCHEMBL8600776 | 0.84 | EPHX1 (0.73) | EPHX1EPHX2ALDH1A1BRD4L3MBTL1 | |
| SCHEMBL23406287 | 0.83 | EPHX1 (0.71) | EPHX1EPHX2ALDH1A1RAB9ANPC1 | |
| SCHEMBL20589978 | 0.83 | EPHX1 (0.71) | EPHX1EPHX2ALDH1A1RAB9ANPC1 | |
| SCHEMBL12196146 | 0.83 | EPHX1 (1.00) | EPHX1EPHX2L3MBTL1RAB9ANPC1 | |
| SCHEMBL12196177 | 0.83 | EPHX1 (1.00) | EPHX1EPHX2ALDH1A1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11806337-B2 | Small molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and uses thereof | Sanford Burnham Prebys Medical Discovery Institute (US) | 2023-11-07 | — | — | US | disclosed |
| US-20210161873-A1 | SMALL MOLECULE ACTIVATORS OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) AND USES THEREOF | Sanford Burnham Prebys Medical Discovery Institute | 2021-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210161873-A1 | SMALL MOLECULE ACTIVATORS OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) AND USES THEREOF | NAMPT, NAPRT, NNT | EPHX1 3475/4885EPHX2 3496/4885ALDH1A1 1943/4885 |
| US-11806337-B2 | Small molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and uses thereof | NAMPT, NAPRT, NNT | EPHX1 3475/4885EPHX2 3496/4885ALDH1A1 1943/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.