Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 18/20 | 0.48 |
| ▸ | JAK1 | P23458 | 18/20 | 0.48 |
| ▸ | JAK3 | P52333 | 18/20 | 0.48 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2345350 | 0.83 | JAK3 (0.54) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL1369481 | 0.82 | JAK3 (0.64) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL2343606 | 0.78 | JAK1 (0.69) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL2351523 | 0.78 | SYK (0.54) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL2340306 | 0.78 | ATR (0.36) | — | |
| SCHEMBL2343199 | 0.74 | JAK3 (0.64) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL1368539 | 0.74 | JAK3 (0.61) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL1368842 | 0.73 | JAK3 (0.62) | JAK2JAK1JAK3TYK2PDE10A | |
| SCHEMBL1368203 | 0.72 | JAK3 (0.67) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL18524459 | 0.71 | SYK (0.61) | JAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247592-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-08-31 | — | — | EP | claimed |