Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 2/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.43 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | XIAP | P98170 | 1/20 | 0.38 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24783495 | 0.82 | CYP11B1 (0.47) | CYP11B1CYP11B2SMYD3CRBNXIAP | |
| SCHEMBL23066125 | 0.76 | AHR (0.51) | SMYD3KIF11PKMTDP1 | |
| SCHEMBL24783492 | 0.76 | AHR (0.51) | SMYD3DDB1CRBNKIF11PKM | |
| SCHEMBL19300242 | 0.76 | CYP11B1 (0.47) | CYP11B1CYP11B2SMYD3DDB1CRBN | |
| SCHEMBL13382908 | 0.76 | SMYD3 (0.43) | CYP11B1CYP11B2SMYD3CRBNXIAP | |
| SCHEMBL25124380 | 0.75 | KIF11 (0.61) | CRBNKIF11PKMALDH1A1L3MBTL1 | |
| SCHEMBL23432587 | 0.75 | CA9 (0.53) | DDB1CRBNKIF11PKMALDH1A1 | |
| SCHEMBL23432581 | 0.74 | KIF11 (0.54) | CYP11B1CYP11B2KIF11PKMALDH1A1 | |
| SCHEMBL12672111 | 0.73 | EPHX2 (0.51) | CYP11B1CYP11B2SMYD3POLBALDH1A1 | |
| SCHEMBL30509174 | 0.73 | EPHX2 (0.51) | CYP11B1CYP11B2SMYD3POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3828174-A1 | PYRIDAZINONE DERIVATIVE | Sumitomo Dainippon Pharma Co., Ltd. (JP) | 2021-06-02 | — | — | EP | disclosed |