Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 5/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.32 |
| ▸ | PDE1A | P54750 | 1/20 | 0.32 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.32 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | TYMP | P19971 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2343998 | 0.86 | CYP11B2 (0.37) | CYP11B1CYP11B2CYP1A2MEN1LMNA | |
| SCHEMBL2157245 | 0.84 | CYP11B2 (0.42) | CYP11B1CYP11B2CYP1A2MEN1KMT2A | |
| SCHEMBL2158156 | 0.83 | MKNK1 (0.39) | CYP11B1CYP11B2CYP1A2MAPTP2RX7 | |
| SCHEMBL8328131 | 0.64 | CYP1A2 (0.41) | CYP11B1CYP11B2CYP1A2LMNAMAPT | |
| SCHEMBL2157283 | 0.64 | CYP11B2 (0.44) | CYP11B1CYP11B2CYP1A2MEN1KMT2A | |
| SCHEMBL7591015 | 0.61 | KCNH2 (0.41) | CYP11B2MAPTKCNH2 | |
| SCHEMBL7590184 | 0.61 | CYP11B2 (0.46) | CYP11B1CYP11B2CYP1A2MEN1KMT2A | |
| SCHEMBL2158205 | 0.61 | KDM4E (0.45) | CYP11B1CYP11B2KMT2AALDH1A1MAOA | |
| SCHEMBL7954864 | 0.59 | CYP11B2 (0.42) | CYP11B1CYP11B2MEN1LMNAMAPT | |
| SCHEMBL8328721 | 0.59 | MKNK1 (0.38) | CYP11B2CYP2A6ALDH1A1P2RX7GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2361253-A1 | COMPOUNDS | Selcia Limited (GB) | 2011-08-31 | — | — | EP | disclosed |
| WO-2010029364-A1 | COMPOUNDS | SELCIA LIMITED (GB) | 2010-03-18 | — | — | WO | disclosed |