L-737126

L-737126

SCHEMBL2344264

NC(=O)c1[nH]c2ccc(Cl)cc2c1S(=O)(=O)c1ccccc1

nearest known ligand 0.61

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAP2 P11137 14/20 0.61
TUBB4A P04350 2/20 0.56
TUBB P07437 2/20 0.56
TUBA3C P0DPH7 2/20 0.56
TUBA1B P68363 2/20 0.56
TUBA4A P68366 2/20 0.56
TUBB4B P68371 2/20 0.56
TUBB3 Q13509 2/20 0.56
TUBB2A Q13885 2/20 0.56
TUBB8 Q3ZCM7 2/20 0.56
TUBA3E Q6PEY2 2/20 0.56
TUBA1A Q71U36 2/20 0.56
TUBA1C Q9BQE3 2/20 0.56
TUBB6 Q9BUF5 2/20 0.56
TUBB2B Q9BVA1 2/20 0.56
TUBB1 Q9H4B7 2/20 0.56
KDM4E B2RXH2 1/20 0.48
ALDH1A1 P00352 1/20 0.48
CA1 P00915 1/20 0.48
CA2 P00918 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
L-737126 SCHEMBL31654105 1.00 MAP2 (0.61) MAP2TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL8938304 0.92 MAP2 (0.59) MAP2TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL8938370 0.91 TUBB4A (0.61) MAP2TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL8687789 0.90 MAP2 (0.59) MAP2TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL2879576 0.89 TUBB4A (0.53) MAP2TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL8938309 0.88 MAP2 (0.58) MAP2TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL8938269 0.88 MAP2 (0.51) MAP2TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL4410863 0.86 KDM4E (0.63) MAP2TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL2881831 0.86 TUBB4A (0.51) MAP2TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL2879565 0.86 TUBB4A (0.51) MAP2TUBB4ATUBBTUBA3CTUBA1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 766 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4133605-B1 DEVICE AND METHOD FOR CANCELLING INTERFERENCE HUAWEI TECH CO LTD (CN) 2026-05-20 EP claimed
CN-222979865-U Two-dimensional metallographic microscope 东莞市贝特森精密仪器有限公司 2025-06-13 CN claimed
CN-118921656-A Privacy protection wireless sensing method and system based on CSI confusion 东南大学 2024-11-08 CN claimed
CN-111782344-B Method, system and host for providing password resources 北京数字认证股份有限公司 2024-06-21 CN claimed
CN-117970301-A Equipment distance measuring method based on WiFi channel state information 西安电子科技大学 2024-05-03 CN claimed
CN-117492828-A Binary translation debugging method and device, computing equipment and storage medium 统信软件技术有限公司 2024-02-02 CN claimed
CN-114401112-B Bypass deployment real-time deep packet detection method for malicious traffic encrypted by TLS 内蒙古农业大学 2023-11-03 CN claimed
US-20230119655-A1 NOVEL CRISPR-CAS SYSTEMS FOR GENOME EDITING PIONEER HI-BRED INTERNATIONAL, INC. (US) 2023-04-20 US claimed
EP-4133605-A1 DEVICE AND METHOD FOR CANCELLING INTERFERENCE Huawei Technologies Co., Ltd. (CN) 2023-02-15 EP claimed
WO-2022268975-A1 METHOD FOR TREATING A PLANT RHODIA OPERATIONS (FR) 2022-12-29 WO claimed
EP-1791537-A1 3-ARYLTHIOINDOLE-2-CARBOXAMIDE DERIVATIVES AND ANALOGS THEREOF AS INHIBITORS OF CASEIN KINASE I Aventis Pharmaceuticals, Inc. (US) 2007-06-06 EP claimed
WO-2006023590-A1 3-ARYLTHIOINDOLE-2-CARBOXAMIDE DERIVATIVES AND ANALOGS THEREOF AS INHIBITORS OF CASEIN KINASE Iϵ AVENTIS PHARMACEUTICALS INC. (US) 2006-03-02 WO claimed
US-20050026902-A1 Methods and compositions for the treatment or prevention of human immunodeficiency virus and related conditions using cyclooxygenase-2 selective inhibitors and antiviral agents PHARMACIA CORPORATION 2005-02-03 US claimed
US-5527819-A TREATING AIDS MERCK & CO., INC. (US) 1996-06-18 US claimed
EP-0686148-A4 INHIBITORS OF HIV REVERSE TRANSCRIPTASE MERCK & CO INC (US) 1996-02-07 EP claimed
EP-0686148-A1 INHIBITORS OF HIV REVERSE TRANSCRIPTASE MERCK & CO. INC. (US) 1995-12-13 EP claimed
EP-0678508-A1 Indoles as inhibitors of HIV reverse transcriptase MERCK & CO. INC. (US) 1995-10-25 EP claimed
WO-1994019321-A1 INHIBITORS OF HIV REVERSE TRANSCRIPTASE MERCK & CO., INC. (US) 1994-09-01 WO claimed
WO-1993005020-A1 INDOLES AS INHIBITORS OF HIV REVERSE TRANSCRIPTASE MERCK & CO., INC. (US) 1993-03-18 WO claimed
EP-0530907-A1 Indoles as inhibitors of HIV reverse transcriptase MERCK & CO. INC. (US) 1993-03-10 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050026902-A1 Methods and compositions for the treatment or prevention of human immunodeficiency virus and related conditions using cyclooxygenase-2 selective inhibitors and antiviral agents PTGS2, PTGS1, PTGES2 MAP2 4296/4885TUBB4A 4545/4885TUBB 4320/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.