Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.40 |
| ▸ | KDM5A | P29375 | 1/20 | 0.40 |
| ▸ | KDM5C | P41229 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | PPIB | P23284 | 1/20 | 0.38 |
| ▸ | PPIA | P62937 | 1/20 | 0.38 |
| ▸ | PPID | Q08752 | 1/20 | 0.38 |
| ▸ | PPIG | Q13427 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25044388 | 0.85 | SMN1; SMN2 (0.48) | SMN1; SMN2TSHRALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL23446458 | 0.80 | NPSR1 (0.50) | SMN1; SMN2TSHRALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL23445929 | 0.79 | RECQL (0.42) | SMN1; SMN2ALDH1A1CYP2C19KDM4EGAA | |
| SCHEMBL22861337 | 0.78 | SMN1; SMN2 (0.63) | SMN1; SMN2ALDH1A1GAAL3MBTL1KMT2A | |
| SCHEMBL31604246 | 0.78 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1CYP1A2KDM4ECYP3A4 | |
| SCHEMBL22166068 | 0.75 | TNF (0.46) | SMN1; SMN2TSHRALDH1A1KDM4EGAA | |
| SCHEMBL22366449 | 0.74 | L3MBTL1 (0.47) | SMN1; SMN2TSHRALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL31467556 | 0.72 | PPID (0.66) | SMN1; SMN2TSHRCYP1A2CYP2C19KDM4E | |
| SCHEMBL509487 | 0.71 | KDM5B (0.53) | ALDH1A1KDM4EGAAKDM5BKDM5A | |
| SCHEMBL10061637 | 0.71 | MAPK13 (0.40) | TSHRALDH1A1CYP1A2KDM4ECYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021105481-A1 | NOVEL COMPOUNDS FOR TREATMENT OF DISEASES RELATED TO DUX4 EXPRESSION | Facio Intellectual Property B.V. (NL) | 2021-06-03 | — | — | WO | disclosed |
| WO-2021105474-A1 | NEW COMPOUNDS FOR TREATMENT OF DISEASES RELATED TO DUX4 EXPRESSION | Facio Intellectual Property B.V. (NL) | 2021-06-03 | — | — | WO | disclosed |