Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 6/20 | 0.33 |
| ▸ | PPARG | P37231 | 5/20 | 0.33 |
| ▸ | PPARD | Q03181 | 5/20 | 0.33 |
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MGLL | Q99685 | 1/20 | 0.31 |
| ▸ | ERN1 | O75460 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23519079 | 0.87 | NOTUM (0.41) | NOTUMFFAR4PPARAPPARDCES2 | |
| SCHEMBL23519066 | 0.77 | NOTUM (0.44) | NOTUMFFAR4PPARAPPARGPPARD | |
| SCHEMBL23519214 | 0.73 | NOTUM (0.62) | NOTUMPPARAPPARGGAA | |
| SCHEMBL1417573 | 0.73 | PPARA (0.43) | PPARAPPARGPPARDKMT2A | |
| SCHEMBL28189505 | 0.73 | HTT (0.45) | CES2CES1GAAKMT2AERN1 | |
| SCHEMBL24361437 | 0.73 | NOTUM (0.46) | NOTUMPPARAPPARGKMT2AMGLL | |
| SCHEMBL9709314 | 0.69 | TSHR (0.38) | NOTUM | |
| SCHEMBL3836775 | 0.69 | RAPGEF4 (0.38) | FFAR4GAA | |
| SCHEMBL23391511 | 0.68 | MAPT (0.37) | — | |
| SCHEMBL17186832 | 0.68 | EPHX2 (0.46) | NOTUMCES2CES1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021108628-A1 | SUBSTITUTED MACROCYCLIC COMPOUNDS AND RELATED METHODS OF TREATMENT | ALKERMES, INC. (US) | 2021-06-03 | — | — | WO | disclosed |