Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.39 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.38 |
| ▸ | MAP2 | P11137 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | GALR2 | O43603 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2344225 | 0.99 | ALDH1A1 (0.43) | ALDH1A1HPGDJAK2MAPTPTGS2 | |
| SCHEMBL2346704 | 0.87 | POLB (0.44) | ALDH1A1MAPTPTGS2PTGS1KDM4E | |
| SCHEMBL2342932 | 0.86 | POLB (0.46) | ALDH1A1MAPTPTGS2PTGS1KDM4E | |
| SCHEMBL2350737 | 0.84 | MAPT (0.51) | ALDH1A1HPGDMAPTPTGS2MAP2 | |
| SCHEMBL2347392 | 0.80 | ALDH1A1 (0.44) | ALDH1A1HPGDJAK2MAPTPTGS2 | |
| SCHEMBL2345144 | 0.78 | MAPT (0.52) | ALDH1A1HPGDMAPTPTGS2SMN1; SMN2 | |
| SCHEMBL3840372 | 0.73 | PPARG (0.35) | ALDH1A1JAK2PTGS2PTGS1KDM4E | |
| SCHEMBL24196941 | 0.73 | ALDH1A1 (0.52) | ALDH1A1HPGDJAK2MAPTPTGS2 | |
| SCHEMBL24196942 | 0.73 | PTGS2 (0.59) | ALDH1A1HPGDMAPTPTGS2KDM4E | |
| SCHEMBL30270452 | 0.73 | ALDH1A1 (0.52) | ALDH1A1HPGDJAK2MAPTPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8008340-B2 | 3-arylthioindole-2-carboxamide derivatives and analogs thereof as inhibitors of casein kinase I | AVENTIS PHARMACEUTICALS INC. (US) | 2011-08-30 | — | — | US | claimed |
| EP-1791537-B1 | 3-ARYLTHIOINDOLE-2-CARBOXAMIDE DERIVATIVES AND ANALOGS THEREOF AS INHIBITORS OF CASEIN KINASE I | AVENTIS PHARMA INC (US) | 2009-10-14 | — | — | EP | claimed |
| US-20070142454-A1 | 3-ARYLTHIOINDOLE-2-CARBOXAMIDE DERIVATIVES AND ANALOGS THEREOF AS INHIBITORS OF CASEIN KINASE I | AVENTIS PHARMACEUTICALS INC. (US) | 2007-06-21 | — | — | US | claimed |
| EP-1791537-A1 | 3-ARYLTHIOINDOLE-2-CARBOXAMIDE DERIVATIVES AND ANALOGS THEREOF AS INHIBITORS OF CASEIN KINASE I | Aventis Pharmaceuticals, Inc. (US) | 2007-06-06 | — | — | EP | claimed |
| WO-2006023590-A1 | 3-ARYLTHIOINDOLE-2-CARBOXAMIDE DERIVATIVES AND ANALOGS THEREOF AS INHIBITORS OF CASEIN KINASE Iϵ | AVENTIS PHARMACEUTICALS INC. (US) | 2006-03-02 | — | — | WO | claimed |
| US-8008340-B2 | 3-arylthioindole-2-carboxamide derivatives and analogs thereof as inhibitors of casein kinase I | AVENTIS PHARMACEUTICALS INC. (US) | 2011-08-30 | — | — | US | disclosed |
| EP-1791537-B1 | 3-ARYLTHIOINDOLE-2-CARBOXAMIDE DERIVATIVES AND ANALOGS THEREOF AS INHIBITORS OF CASEIN KINASE I | AVENTIS PHARMA INC (US) | 2009-10-14 | — | — | EP | disclosed |
| US-20070142454-A1 | 3-ARYLTHIOINDOLE-2-CARBOXAMIDE DERIVATIVES AND ANALOGS THEREOF AS INHIBITORS OF CASEIN KINASE I | AVENTIS PHARMACEUTICALS INC. (US) | 2007-06-21 | — | — | US | disclosed |
| EP-1791537-A1 | 3-ARYLTHIOINDOLE-2-CARBOXAMIDE DERIVATIVES AND ANALOGS THEREOF AS INHIBITORS OF CASEIN KINASE I | Aventis Pharmaceuticals, Inc. (US) | 2007-06-06 | — | — | EP | disclosed |
| WO-2006023590-A1 | 3-ARYLTHIOINDOLE-2-CARBOXAMIDE DERIVATIVES AND ANALOGS THEREOF AS INHIBITORS OF CASEIN KINASE Iϵ | AVENTIS PHARMACEUTICALS INC. (US) | 2006-03-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070142454-A1 | 3-ARYLTHIOINDOLE-2-CARBOXAMIDE DERIVATIVES AND ANALOGS THEREOF AS INHIBITORS OF CASEIN KINASE I | CSNK1A1, CSNK1E, CSNK1D | ALDH1A1 2916/4885HPGD 3459/4885JAK2 925/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.