⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8944270 | 0.70 | ACHE (0.42) | — | |
| SCHEMBL10845488 | 0.70 | — | — | |
| SCHEMBL2353862 | 0.69 | MAPK1 (0.39) | — | |
| SCHEMBL24581053 | 0.68 | PDK1 (0.37) | — | |
| SCHEMBL9561724 | 0.68 | PDK1 (0.37) | — | |
| SCHEMBL14677398 | 0.65 | — | — | |
| SCHEMBL24965098 | 0.63 | — | — | |
| SCHEMBL7975172 | 0.63 | TSHR (0.35) | — | |
| SCHEMBL23465968 | 0.59 | — | — | |
| SCHEMBL24410520 | 0.59 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240366620-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR CANCER PATIENT STRATIFICATION AND CANCER TREATMENT | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2024-11-07 | — | — | US | disclosed |
| EP-3334404-B1 | COMPOSITIONS AND METHODS FOR CANCER EXPRESSING PDE3A AND SLFN12 | BROAD INST INC (US) | 2024-09-18 | — | — | EP | disclosed |
| US-12053476-B2 | Compounds, compositions and methods for cancer patient stratification and cancer treatment | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2024-08-06 | — | — | US | disclosed |
| CN-108883112-B | Compounds, compositions and methods for cancer patient stratification and cancer treatment | 拜耳医药股份公司 | 2022-07-26 | — | — | CN | disclosed |
| CN-114699528-A | Compositions and methods for PDE3A or SLFN12 expressing cancers | 布罗德研究所股份有限公司 | 2022-07-05 | — | — | CN | disclosed |
| CN-114601837-A | Compounds, compositions and methods for cancer patient stratification and cancer treatment | 拜耳医药股份公司 | 2022-06-10 | — | — | CN | disclosed |
| CN-108366947-B | Compositions and methods for PDE3A or SLFN12 expressing cancers | 布罗德研究所股份有限公司 | 2022-03-29 | — | — | CN | disclosed |
| US-20220071995-A1 | COMPOSITIONS AND METHODS FOR CANCER EXPRESSING PDE3A OR SLFN12 | THE BROAD INSTITUTE, INC. (US) | 2022-03-10 | — | — | US | disclosed |
| CN-111235593-B | Synthesis method of nitrogen nitrosation product of secondary amine | 南京理工大学 | 2020-10-16 | — | — | CN | disclosed |
| CN-111235593-A | Synthesis method of nitrogen nitrosation product of secondary amine | 南京理工大学 | 2020-06-05 | — | — | CN | disclosed |
| EP-2536483-B1 | SOLVENT TREATMENT PROCESS | COMMW SCIENT IND RES ORG (AU) | 2017-05-31 | — | — | EP | disclosed |
| US-20130053614-A1 | SOLVENT TREATMENT PROCESS | COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH OR (AU) | 2013-02-28 | — | — | US | disclosed |
| EP-2536483-A1 | SOLVENT TREATMENT PROCESS | Commonwealth Scientific and Industrial Research Organisation (AU) | 2012-12-26 | — | — | EP | disclosed |
| WO-2011100801-A1 | SOLVENT TREATMENT PROCESS | COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) | 2011-08-25 | — | — | WO | disclosed |