Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 8/20 | 0.46 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 2/20 | 0.41 |
| ▸ | CTSD | P07339 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | TEC | P42680 | 1/20 | 0.41 |
| ▸ | CD69 | Q07108 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 2/20 | 0.40 |
| ▸ | FPR2 | P25090 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | CCNK | O75909 | 1/20 | 0.39 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30111813 | 1.00 | BTK (0.46) | BTKHCAR1HTR6HPGDSBACE1 | |
| SCHEMBL18289974 | 1.00 | BTK (0.46) | BTKHCAR1HTR6HPGDSBACE1 | |
| SCHEMBL18644666 | 0.94 | SRC (0.45) | BTKHCAR1HPGDSBACE1CTSD | |
| SCHEMBL18285551 | 0.85 | BTK (0.45) | BTKEGFRTECCD69JAK2 | |
| SCHEMBL18285554 | 0.85 | BTK (0.45) | BTKEGFRTECCD69JAK2 | |
| SCHEMBL29737131 | 0.85 | KDM4E (0.37) | BTKHCAR1EGFRSRCPIK3CA | |
| SCHEMBL24590579 | 0.85 | KDM4E (0.37) | BTKHCAR1EGFRSRCPIK3CA | |
| SCHEMBL16321781 | 0.85 | SRC (0.49) | BTKHCAR1HPGDSBACE1CTSD | |
| SCHEMBL16321782 | 0.85 | SRC (0.49) | BTKHCAR1HPGDSBACE1CTSD | |
| SCHEMBL18818279 | 0.83 | HCAR1 (0.41) | BTKHCAR1HTR6HPGDSFPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3303334-B1 | TYROSINE KINASE INHIBITORS | PRINCIPIA BIOPHARMA INC (US) | 2021-06-02 | — | — | EP | disclosed |