Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of Feniralstat. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 20/20 | 0.94 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Feniralstat SCHEMBL23456746 | 0.98 | KLKB1 (0.94) | KLKB1CYP3A4CYP2C8CYP2C9 | |
| Feniralstat SCHEMBL21145564 | 0.97 | KLKB1 (1.00) | KLKB1CYP3A4CYP2C8CYP2C9 | |
| Feniralstat SCHEMBL22491847 | 0.96 | KLKB1 (0.90) | KLKB1CYP3A4CYP2C8CYP2C9 | |
| Feniralstat SCHEMBL23456766 | 0.96 | KLKB1 (0.98) | KLKB1CYP3A4CYP2C8CYP2C9 | |
| Feniralstat SCHEMBL29619265 | 0.96 | KLKB1 (0.98) | KLKB1CYP3A4CYP2C8CYP2C9 | |
| Feniralstat SCHEMBL28433437 | 0.95 | KLKB1 (0.87) | KLKB1CYP3A4CYP2C8CYP2C9 | |
| Feniralstat SCHEMBL23456760 | 0.95 | KLKB1 (0.95) | KLKB1CYP3A4CYP2C8CYP2C9 | |
| Feniralstat SCHEMBL22491814 | 0.94 | KLKB1 (0.85) | KLKB1CYP3A4CYP2C8CYP2C9 | |
| Feniralstat SCHEMBL23456765 | 0.93 | KLKB1 (0.84) | KLKB1CYP3A4CYP2C8CYP2C9 | |
| Sebetralstat SCHEMBL22495499 | 0.90 | KLKB1 (0.94) | KLKB1CYP3A4CYP2C8CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230203012-A1 | SOLID FORMS OF A PLASMA KALLIKREIN INHIBITOR AND SALTS THEREOF | CROWE DAVID MALCOLM (GB) | 2023-06-29 | — | — | US | disclosed |
| US-11584735-B2 | Solid forms of a plasma kallikrein inhibitor and salts thereof | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2023-02-21 | — | — | US | disclosed |
| US-20210171496-A1 | SOLID FORMS OF A PLASMA KALLIKREIN INHIBITOR AND SALTS THEREOF | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2021-06-10 | — | — | US | disclosed |
| CN-111433197-A | Solid forms of plasma kallikrein inhibitors and salts thereof | 卡尔维斯塔制药有限公司 | 2020-07-17 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11584735-B2 | Solid forms of a plasma kallikrein inhibitor and salts thereof | KLKB1, KLK1, KLK2 | KLKB1 1/4885CYP3A4 1270/4885CYP2C8 1744/4885 |
| US-20210171496-A1 | SOLID FORMS OF A PLASMA KALLIKREIN INHIBITOR AND SALTS THEREOF | KLKB1, KLK1, KLK2 | KLKB1 1/4885CYP3A4 1270/4885CYP2C8 1744/4885 |
| US-20230203012-A1 | SOLID FORMS OF A PLASMA KALLIKREIN INHIBITOR AND SALTS THEREOF | KLKB1, KLK1, KLK2 | KLKB1 1/4885CYP3A4 1218/4885CYP2C8 1933/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.