Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 3/20 | 0.70 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | TNF | P01375 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | APAF1 | O14727 | 2/20 | 0.41 |
| ▸ | NSD2 | O96028 | 2/20 | 0.41 |
| ▸ | CASP3 | P42574 | 2/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23457647 | 0.90 | ACHE (0.78) | ACHEL3MBTL1TNFRAB9AAPAF1 | |
| SCHEMBL21690579 | 0.87 | ACHE (0.79) | ACHEL3MBTL1TNFRAB9AAPAF1 | |
| SCHEMBL21690571 | 0.87 | ACHE (0.74) | ACHEL3MBTL1TNFRAB9AAPAF1 | |
| SCHEMBL23457737 | 0.86 | ACHE (0.60) | ACHEL3MBTL1TNFRAB9AAPAF1 | |
| SCHEMBL23457402 | 0.83 | ACHE (0.76) | ACHEL3MBTL1TNFRAB9AAPAF1 | |
| SCHEMBL23457478 | 0.82 | ACHE (0.78) | ACHEL3MBTL1TNFRAB9AAPAF1 | |
| SCHEMBL21690580 | 0.80 | ACHE (0.67) | ACHEL3MBTL1TNFRAB9AAPAF1 | |
| SCHEMBL23457420 | 0.79 | ACHE (0.77) | ACHEL3MBTL1TNFAPAF1NSD2 | |
| SCHEMBL23457941 | 0.75 | ACHE (0.70) | ACHEL3MBTL1MEN1KMT2ACYP3A4 | |
| SCHEMBL35210113 | 0.74 | ACHE (0.67) | ACHEL3MBTL1TNFAPAF1NSD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210163453-A1 | DERIVATIVES OF PAPAVERINE THAT ARE EFFECTIVE HYPOXIC TUMOR RADIOSENSITIZERS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2021-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210163453-A1 | DERIVATIVES OF PAPAVERINE THAT ARE EFFECTIVE HYPOXIC TUMOR RADIOSENSITIZERS | HIF1AN, HIF1A, HYOU1 | ACHE 2115/4885L3MBTL1 3551/4885TNF 4466/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.