Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.37 |
| ▸ | CDC42BPA | Q5VT25 | 2/20 | 0.37 |
| ▸ | CDC42BPB | Q9Y5S2 | 2/20 | 0.37 |
| ▸ | SYK | P43405 | 14/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3401593 | 0.90 | SYK (0.36) | ROCK2ROCK1CDC42BPACDC42BPBSYK | |
| SCHEMBL1887679 | 0.82 | JAK3 (0.47) | SYK | |
| SCHEMBL3397988 | 0.73 | LRRK2 (0.39) | SYKMAPK1PIM1 | |
| SCHEMBL3399528 | 0.73 | LRRK2 (0.39) | SYKMAPK1PIM1 | |
| SCHEMBL2341240 | 0.72 | LRRK2 (0.38) | SYKMAPK1 | |
| SCHEMBL3399555 | 0.72 | ITGB2 (0.39) | ROCK2ROCK1CDC42BPBMAPK1PIM1 | |
| SCHEMBL3396373 | 0.71 | JAK3 (0.44) | MAPK1 | |
| SCHEMBL3401949 | 0.71 | MAPK1 (0.35) | MAPK1 | |
| SCHEMBL3397858 | 0.71 | HRH4 (0.42) | ROCK2ROCK1CDC42BPACDC42BPB | |
| SCHEMBL3400811 | 0.69 | ADK (0.48) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247592-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-08-31 | — | — | EP | claimed |