Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.38 |
| ▸ | GPR52 | Q9Y2T5 | 7/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CD38 | P28907 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23458147 | 0.87 | MAPK13 (0.35) | PARP1RAB9A | |
| SCHEMBL31264104 | 0.86 | MRGPRX4 (0.33) | PARP1CD38RAB9AKDM4EAURKA | |
| SCHEMBL31443297 | 0.85 | RAB9A (0.33) | RAB9A | |
| SCHEMBL31111624 | 0.84 | KMT2A (0.32) | LMNARAB9AKDM4EL3MBTL1 | |
| SCHEMBL2254723 | 0.82 | TRPV1 (0.40) | LMNARAB9AKDM4EL3MBTL1 | |
| SCHEMBL3884176 | 0.81 | TRPV1 (0.36) | RAB9AKDM4E | |
| SCHEMBL9987868 | 0.81 | MAPK13 (0.39) | LMNARAB9AKDM4E | |
| SCHEMBL30605929 | 0.80 | MEN1 (0.37) | LMNARAB9AKDM4EAURKAAURKB | |
| SCHEMBL26134079 | 0.80 | MEN1 (0.37) | LMNARAB9AKDM4EAURKAAURKB | |
| SCHEMBL24761235 | 0.79 | ERCC5 (0.47) | RAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4069692-A1 | N-(3-(5-(PYRIMIDIN-4-YL)THIAZOL-4-YL)PHENYL)SULFONAMIDE COMPOUNDS AND THEIR USES AS BRAF INHIBITORS | Institut National de la Santé et de la Recherche Médicale (INSERM) (FR) | 2022-10-12 | — | — | EP | disclosed |
| WO-2021110997-A1 | N-(3-(5-(PYRIMIDIN-4-YL)THIAZOL-4-YL)PHENYL)SULFONAMIDE COMPOUNDS AND THEIR USES AS BRAF INHIBITORS | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2021-06-10 | — | — | WO | disclosed |