Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 1/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | KMO | O15229 | 1/20 | 0.32 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | GABRP | O00591 | 1/20 | 0.30 |
| ▸ | GABRD | O14764 | 1/20 | 0.30 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.30 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.30 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.30 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23458145 | 0.87 | PARP1 (0.38) | RAB9APARP1 | |
| SCHEMBL31443297 | 0.85 | RAB9A (0.33) | RAB9ANPC1KMOTP53MAPT | |
| SCHEMBL31264104 | 0.84 | MRGPRX4 (0.33) | RAB9ANPC1KMOTP53MAPT | |
| SCHEMBL2254723 | 0.82 | TRPV1 (0.40) | RAB9ANPC1TRPV1KMT2A | |
| SCHEMBL31111624 | 0.82 | KMT2A (0.32) | RAB9AMAPTTRPV1KMT2A | |
| SCHEMBL9987868 | 0.81 | MAPK13 (0.39) | MAPK13MAPK12MAPK11MAPK14RAB9A | |
| SCHEMBL3884176 | 0.81 | TRPV1 (0.36) | MAPK13MAPK12MAPK11MAPK14RAB9A | |
| SCHEMBL30605929 | 0.80 | MEN1 (0.37) | RAB9ANPC1TRPV1KMT2A | |
| SCHEMBL26134079 | 0.80 | MEN1 (0.37) | RAB9ANPC1TRPV1KMT2A | |
| SCHEMBL24761235 | 0.79 | ERCC5 (0.47) | RAB9ANPC1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4069692-A1 | N-(3-(5-(PYRIMIDIN-4-YL)THIAZOL-4-YL)PHENYL)SULFONAMIDE COMPOUNDS AND THEIR USES AS BRAF INHIBITORS | Institut National de la Santé et de la Recherche Médicale (INSERM) (FR) | 2022-10-12 | — | — | EP | disclosed |
| WO-2021110997-A1 | N-(3-(5-(PYRIMIDIN-4-YL)THIAZOL-4-YL)PHENYL)SULFONAMIDE COMPOUNDS AND THEIR USES AS BRAF INHIBITORS | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2021-06-10 | — | — | WO | disclosed |