Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABHD6 | Q9BV23 | 6/20 | 0.41 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | BAZ2B | Q9UIF8 | 2/20 | 0.32 |
| ▸ | ESR1 | P03372 | 2/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23458633 | 0.84 | PTPN2 (0.34) | ABHD6ACACBBAZ2BESR1ESR2 | |
| SCHEMBL22775930 | 0.81 | ESR2 (0.50) | ABHD6ESR2ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL29522876 | 0.81 | ESR2 (0.50) | ABHD6ESR2ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL30068990 | 0.79 | SPR (0.39) | ABHD6BAZ2BESR1ESR2ALDH1A1 | |
| SCHEMBL29150748 | 0.79 | SPR (0.39) | ABHD6BAZ2BESR1ESR2ALDH1A1 | |
| SCHEMBL29168587 | 0.78 | ABHD6 (0.36) | ABHD6BAZ2BALDH1A1HPGDHTT | |
| SCHEMBL29168642 | 0.77 | KMT2A (0.36) | ABHD6ALDH1A1HPGDKDM4ETSHR | |
| SCHEMBL23705993 | 0.77 | ESR1 (0.47) | ABHD6ACACBESR1ESR2ALDH1A1 | |
| SCHEMBL30204981 | 0.77 | ACACB (0.49) | ABHD6ACACBESR1ESR2HPGD | |
| SCHEMBL29236998 | 0.75 | ABHD6 (0.32) | ABHD6BAZ2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114026094-B | PRMT5 inhibitors | 印度鲁宾有限公司 | 2024-06-25 | — | — | CN | disclosed |
| EP-4069698-A1 | SUBSTITUTED NUCLEOSIDE ANALOGS AS PRMT5 INHIBITORS | Lupin Limited (IN) | 2022-10-12 | — | — | EP | disclosed |
| CN-115135651-A | Substituted nucleoside analogs as PRMT5 inhibitors | 鲁皮恩有限公司 | 2022-09-30 | — | — | CN | disclosed |
| CN-114026094-A | PRMT5 inhibitor | 印度鲁宾有限公司 | 2022-02-08 | — | — | CN | disclosed |
| WO-2021111322-A1 | SUBSTITUTED NUCLEOSIDE ANALOGS AS PRMT5 INHIBITORS | LUPIN LIMITED (IN) | 2021-06-10 | — | — | WO | disclosed |