Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | JAK2 | O60674 | 5/20 | 0.50 |
| ▸ | JAK1 | P23458 | 5/20 | 0.50 |
| ▸ | TYK2 | P29597 | 5/20 | 0.50 |
| ▸ | JAK3 | P52333 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28662530 | 0.85 | JAK2 (0.47) | ALDH1A1LMNAMAPTHPGDJAK2 | |
| SCHEMBL502084 | 0.83 | ATM (0.51) | ALDH1A1LMNANPSR1MAPTJAK2 | |
| SCHEMBL31369031 | 0.83 | JAK2 (0.50) | ALDH1A1LMNAMAPTHPGDJAK2 | |
| SCHEMBL2422229 | 0.83 | JAK2 (0.50) | ALDH1A1LMNAMAPTHPGDJAK2 | |
| SCHEMBL2337440 | 0.82 | TYK2 (0.55) | JAK2JAK1TYK2JAK3PDE4D | |
| SCHEMBL15698666 | 0.81 | LMNA (0.49) | ALDH1A1LMNATSHRNPSR1MAPT | |
| SCHEMBL15713530 | 0.81 | TYK2 (0.65) | ALDH1A1MAPTJAK2JAK1TYK2 | |
| SCHEMBL24498001 | 0.81 | TYK2 (0.51) | ALDH1A1LMNATSHRMAPTHPGD | |
| SCHEMBL5622755 | 0.79 | KMT2A (0.58) | ALDH1A1MAPTHPGDSMN1; SMN2MEN1 | |
| SCHEMBL5623355 | 0.79 | DHODH (0.53) | ALDH1A1MAPTSMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110230467-A1 | 4,6-DIAMINONICOTINAMIDE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2011-09-22 | — | — | US | disclosed |
| US-20110230467-A1 | 4,6-DIAMINONICOTINAMIDE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2011-09-22 | — | — | US | disclosed |
| US-20110230467-A1 | 4,6-DIAMINONICOTINAMIDE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2011-09-22 | — | — | US | disclosed |
| EP-2361902-A1 | 4,6-DIAMINONICOTINAMIDE COMPOUND | Astellas Pharma Inc. (JP) | 2011-08-31 | — | — | EP | disclosed |
| WO-2010058846-A1 | 4,6-DIAMINONICOTINAMIDE COMPOUND | アステラス製薬株式会社 (JP) | 2010-05-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110230467-A1 | 4,6-DIAMINONICOTINAMIDE COMPOUND | JAK3, JAK2, JAK1 | ALDH1A1 1378/4885LMNA 4693/4885TSHR 1880/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.