Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 5/20 | 0.50 |
| ▸ | JAK1 | P23458 | 5/20 | 0.50 |
| ▸ | TYK2 | P29597 | 5/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 3/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.41 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2422229 | 1.00 | JAK2 (0.50) | JAK2JAK1TYK2PDE4DMAPT | |
| SCHEMBL2337440 | 0.88 | TYK2 (0.55) | JAK2JAK1TYK2PDE4DJAK3 | |
| SCHEMBL15713530 | 0.87 | TYK2 (0.65) | JAK2JAK1TYK2PDE4DMAPT | |
| SCHEMBL28662530 | 0.86 | JAK2 (0.47) | JAK2JAK1TYK2PDE4DMAPT | |
| SCHEMBL24498001 | 0.84 | TYK2 (0.51) | JAK2JAK1TYK2PDE4DMAPT | |
| SCHEMBL17688897 | 0.84 | AKR1C3 (0.48) | MAPTMEN1KMT2AAKR1C3LMNA | |
| SCHEMBL2345978 | 0.83 | ALDH1A1 (0.53) | JAK2JAK1TYK2PDE4DMAPT | |
| SCHEMBL31369054 | 0.82 | JAK2 (0.44) | JAK2JAK1TYK2PDE4DMAPT | |
| SCHEMBL28656448 | 0.82 | JAK2 (0.44) | JAK2JAK1TYK2PDE4DMAPT | |
| SCHEMBL21600853 | 0.80 | MAPT (0.55) | JAK2JAK1TYK2PDE4DMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113563309-B | Pyridine derivative and preparation method and application thereof | 浙江海正药业股份有限公司 | 2024-12-13 | — | — | CN | disclosed |