Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | PRCP | P42785 | 6/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13881895 | 1.00 | ATM (0.54) | ATML3MBTL1CYP2D6CYP3A4SMN1; SMN2 | |
| SCHEMBL23425965 | 1.00 | ATM (0.54) | ATML3MBTL1CYP2D6CYP3A4SMN1; SMN2 | |
| SCHEMBL13713126 | 0.86 | ATM (0.41) | ATML3MBTL1ALDH1A1CYP1A2CHRM3 | |
| SCHEMBL2612760 | 0.82 | ATM (0.49) | ATML3MBTL1CYP2D6CYP3A4SMN1; SMN2 | |
| SCHEMBL6784593 | 0.82 | ATM (0.49) | ATML3MBTL1CYP2D6CYP3A4SMN1; SMN2 | |
| SCHEMBL18923903 | 0.82 | ATM (0.49) | ATML3MBTL1CYP2D6CYP3A4SMN1; SMN2 | |
| SCHEMBL12928730 | 0.76 | L3MBTL1 (0.45) | ATML3MBTL1CYP2D6CYP3A4SMN1; SMN2 | |
| SCHEMBL1047497 | 0.76 | L3MBTL1 (0.49) | ATML3MBTL1CYP2D6CYP3A4SMN1; SMN2 | |
| SCHEMBL12928749 | 0.76 | L3MBTL1 (0.45) | ATML3MBTL1CYP2D6CYP3A4SMN1; SMN2 | |
| SCHEMBL12928741 | 0.76 | L3MBTL1 (0.45) | ATML3MBTL1CYP2D6CYP3A4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11028085-B2 | Substituted isoindolin-1-ones and 2,3-dihydro-1h-pyrrolo[3,4-c]pyridin-1-ones as hpk1 antagonists | Nimbus Saturn, Inc. (US) | 2021-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11028085-B2 | Substituted isoindolin-1-ones and 2,3-dihydro-1h-pyrrolo[3,4-c]pyridin-1-ones as hpk1 antagonists | HIPK1, PDXK, IP6K1 | ATM 1455/4885L3MBTL1 2183/4885CYP2D6 2694/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.