Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 16/20 | 0.62 |
| ▸ | WDR77 | Q9BQA1 | 8/20 | 0.62 |
| ▸ | METTL3 | Q86U44 | 8/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23469007 | 0.92 | PRMT5 (0.67) | PRMT5WDR77METTL3 | |
| SCHEMBL23468987 | 0.91 | PRMT5 (0.56) | PRMT5WDR77METTL3 | |
| SCHEMBL20733572 | 0.88 | PRMT5 (0.62) | PRMT5WDR77METTL3 | |
| SCHEMBL24199739 | 0.83 | METTL3 (0.70) | PRMT5WDR77METTL3 | |
| SCHEMBL20733574 | 0.83 | METTL3 (0.70) | PRMT5WDR77METTL3 | |
| SCHEMBL23469003 | 0.82 | PRMT5 (0.47) | PRMT5WDR77METTL3 | |
| SCHEMBL23469010 | 0.81 | PRMT5 (0.59) | PRMT5WDR77METTL3 | |
| SCHEMBL23544713 | 0.81 | PRMT5 (0.64) | PRMT5WDR77METTL3 | |
| SCHEMBL23469018 | 0.81 | PRMT5 (0.59) | PRMT5WDR77METTL3 | |
| SCHEMBL20733628 | 0.81 | PRMT5 (0.73) | PRMT5WDR77METTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3939986-A1 | SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5) | Prelude Therapeutics, Incorporated (US) | 2022-01-19 | — | — | EP | disclosed |
| EP-3665179-B1 | SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5) | PRELUDE THERAPEUTICS INC (US) | 2021-06-09 | — | — | EP | disclosed |