Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 6/20 | 0.43 |
| ▸ | TLR7 | Q9NYK1 | 6/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.38 |
| ▸ | TMIGD3 | P0DMS9 | 2/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | TSHR | P16473 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20219500 | 0.89 | CYP1A2 (0.47) | TLR8TLR7CYP1A2CYP3A4LMNA | |
| SCHEMBL20219267 | 0.83 | TLR7 (0.44) | TLR8TLR7CYP1A2CYP3A4TMIGD3 | |
| SCHEMBL23472141 | 0.83 | SMN1; SMN2 (0.50) | LMNATSHRSMN1; SMN2KDM4ENPC1 | |
| SCHEMBL23472065 | 0.82 | TLR8 (0.43) | TLR8TLR7CYP1A2CYP3A4TMIGD3 | |
| SCHEMBL20219532 | 0.82 | TLR7 (0.54) | TLR8TLR7CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL23472276 | 0.81 | TLR7 (0.37) | TLR8TLR7LMNAALDH1A1TSHR | |
| SCHEMBL23472249 | 0.80 | PDE5A (0.40) | TLR8TLR7CYP1A2CYP3A4LMNA | |
| SCHEMBL23472214 | 0.79 | CYP1A2 (0.39) | TLR8TLR7CYP1A2CYP3A4LMNA | |
| SCHEMBL20219660 | 0.77 | TLR7 (0.49) | TLR8TLR7CYP1A2CYP3A4LMNA | |
| SCHEMBL23472267 | 0.74 | CYP1A2 (0.47) | TLR8TLR7CYP1A2CYP3A4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3590928-B1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2021-06-09 | — | — | EP | disclosed |