Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | STAT3 | P40763 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23472141 | 0.85 | SMN1; SMN2 (0.50) | SMN1; SMN2MAPK1LMNAMEN1STAT3 | |
| SCHEMBL23472065 | 0.84 | TLR8 (0.43) | TLR7TLR8ALDH1A1HPGDTP53 | |
| SCHEMBL20219768 | 0.83 | TLR7 (0.47) | TLR7TLR8 | |
| SCHEMBL23472382 | 0.81 | TLR8 (0.43) | TLR7TLR8ALDH1A1HPGDTP53 | |
| SCHEMBL20219267 | 0.81 | TLR7 (0.44) | TLR7TLR8ALDH1A1HPGDTP53 | |
| SCHEMBL20219500 | 0.80 | CYP1A2 (0.47) | TLR7TLR8ALDH1A1HPGDTP53 | |
| SCHEMBL23472249 | 0.79 | PDE5A (0.40) | TLR7TLR8ALDH1A1LMNA | |
| SCHEMBL20219258 | 0.75 | TLR7 (0.44) | TLR7TLR8 | |
| SCHEMBL20219660 | 0.73 | TLR7 (0.49) | TLR7TLR8ALDH1A1HPGDTP53 | |
| SCHEMBL23472599 | 0.71 | CYP1A2 (0.44) | TLR7TLR8ALDH1A1TP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3590928-B1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2021-06-09 | — | — | EP | disclosed |