Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.39 |
| ▸ | SRC | P12931 | 4/20 | 0.37 |
| ▸ | ABL1 | P00519 | 3/20 | 0.37 |
| ▸ | CASP6 | P55212 | 1/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.36 |
| ▸ | FLT3 | P36888 | 5/20 | 0.36 |
| ▸ | TYRO3 | Q06418 | 4/20 | 0.36 |
| ▸ | MERTK | Q12866 | 4/20 | 0.36 |
| ▸ | GAS6 | Q14393 | 4/20 | 0.36 |
| ▸ | AXL | P30530 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ACP1 | P24666 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23472189 | 0.84 | TLR8 (0.41) | TLR8SRCABL1CASP6TLR7 | |
| SCHEMBL20219679 | 0.83 | TLR8 (0.40) | TLR8SRCABL1CASP6TLR7 | |
| SCHEMBL13195744 | 0.83 | TLR8 (0.50) | TLR8TLR7CYP1A2CYP2D6L3MBTL1 | |
| SCHEMBL15469963 | 0.83 | TLR8 (0.50) | TLR8TLR7CYP1A2CYP2D6L3MBTL1 | |
| SCHEMBL15469961 | 0.83 | TLR8 (0.50) | TLR8TLR7CYP1A2CYP2D6L3MBTL1 | |
| SCHEMBL15469957 | 0.81 | TLR8 (0.47) | TLR8TLR7CYP1A2CYP2D6L3MBTL1 | |
| SCHEMBL20219420 | 0.80 | CALM1 (0.35) | TLR8 | |
| SCHEMBL20219506 | 0.78 | SRC (0.44) | TLR8SRCABL1TLR7CYP1A2 | |
| SCHEMBL20219474 | 0.76 | TLR8 (0.33) | TLR8TLR7FLT3TYRO3MERTK | |
| SCHEMBL23472515 | 0.76 | APP (0.47) | TLR8SRCTLR7CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3590928-B1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2021-06-09 | — | — | EP | disclosed |