Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 5/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 4/20 | 0.39 |
| ▸ | ABL1 | P00519 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ACP1 | P24666 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | CASP6 | P55212 | 1/20 | 0.36 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23472189 | 0.87 | TLR8 (0.41) | TLR8TLR7CYP1A2CYP2D6SRC | |
| SCHEMBL15469963 | 0.86 | TLR8 (0.50) | TLR8TLR7CYP1A2CYP2D6L3MBTL1 | |
| SCHEMBL15469961 | 0.86 | TLR8 (0.50) | TLR8TLR7CYP1A2CYP2D6L3MBTL1 | |
| SCHEMBL13195744 | 0.86 | TLR8 (0.50) | TLR8TLR7CYP1A2CYP2D6L3MBTL1 | |
| SCHEMBL15469957 | 0.84 | TLR8 (0.47) | TLR8TLR7CYP1A2CYP2D6L3MBTL1 | |
| SCHEMBL23472446 | 0.83 | TLR8 (0.39) | TLR8TLR7CYP1A2CYP2D6SRC | |
| SCHEMBL20219506 | 0.81 | SRC (0.44) | TLR8TLR7CYP1A2CYP2D6SRC | |
| SCHEMBL20219480 | 0.79 | LMNA (0.45) | TLR8CYP1A2CYP2D6SRCABL1 | |
| SCHEMBL23472515 | 0.79 | APP (0.47) | TLR8TLR7CYP1A2CYP2D6SRC | |
| SCHEMBL23472169 | 0.74 | TLR8 (0.41) | TLR8TLR7CYP1A2CYP2D6SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3330257-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | Janssen Sciences Ireland UC (IE) | 2018-06-06 | — | — | EP | disclosed |