Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 3/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 9/20 | 0.32 |
| ▸ | TLR8 | Q9NR97 | 7/20 | 0.32 |
| ▸ | PDE1A | P54750 | 1/20 | 0.32 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.32 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23472650 | 0.91 | CRHR1 (0.34) | CRHR1TLR7TLR8 | |
| SCHEMBL20386630 | 0.86 | TLR7 (0.42) | TLR7TLR8 | |
| SCHEMBL15470301 | 0.86 | TLR7 (0.42) | TLR7TLR8 | |
| SCHEMBL20219542 | 0.80 | TLR8 (0.43) | TLR7TLR8 | |
| SCHEMBL15470288 | 0.80 | TLR8 (0.43) | TLR7TLR8 | |
| SCHEMBL15470272 | 0.79 | KCNH2 (0.45) | TLR7TLR8 | |
| SCHEMBL20219549 | 0.79 | KCNH2 (0.45) | TLR7TLR8 | |
| SCHEMBL20386621 | 0.78 | KCNH2 (0.34) | TLR7TLR8 | |
| SCHEMBL23472172 | 0.76 | AGXT (0.39) | CRHR1TLR7TLR8 | |
| SCHEMBL20219678 | 0.76 | TLR8 (0.41) | TLR7TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3590928-B1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2021-06-09 | — | — | EP | disclosed |